Maria Neve Ombra


Maria Neve Ombra, Dr.


Direct: +39 0825 299411

Short CV

Research Interests

Epigenetic mechanisms involved in transcriptional gene regulation by oestrogen, in breast cancer cell lines.

Interest in the field of dietary chemoprevention, which refers to the use of naturally occurring molecules to prevent or retard tumor development. Understanding of the molecular mechanisms underlying the protective role of specific micronutrients on the onset and progression of the disease.

Field of expertise: cellular and molecular biology. Bioassays with plant extracts for isolation of anti-proliferative compounds.

Key Publications

Perillo B, Di Santi A, Cernera G, Ombra MN, Castoria G, Migliaccio A. Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS. The role of Akt, IKKα, and DNA damage repair enzymes. Nucleus. 2014 5(5) 482-491.
DOI: 10.4161/nucl.36274

Ombra MN, Fratianni F, Granese T, Cardinale F, Cozzolino A, Nazzaro F. In vitro antioxidant, antimicrobial and anti-proliferative activities of purple potato extracts (Solanum tuberosum cv Vitelotte noire) following simulated gastro-intestinal digestion. Natural Product Research (in press). DOI: 10.1080/14786419.2014.981183

Palomba G, Atzori F, Budroni M, Ombra MN, Cossu A, Sini MC, Pusceddu V, Massidda B, Frau B, Notary F, Ionta MT, Palmieri G. ERCC1 polymorphisms as prognostic markers in T4 breast cancer patients treated with platinum-based chemotherapy. Journal of Translational Medicine. 2014 12(1), 272:1-8 doi: 10.1186/s12967-014-0272-4

Perillo B, Di Santi A, Cernera G, Ombra MN, Castoria G, Migliaccio A. Phosphorylation of H3 serine 10 by IKKα governs cyclical production of ROS in estrogen-induced transcription and ensures DNA wholeness. Cell Death Differ. 2014 21(9):1503. doi: 10.1038/cdd.2014.91

Ombra MN, Di Santi A, Abbondanza C, Migliaccio A, Avvedimento EV, Perillo B. Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA. Biochim Biophys Acta. 2013 1829(5):480-6. doi:10.1016/j.bbagrm.2013.03.003

Abbondanza C, De Rosa C, Ombra MN, Aceto F, Medici N, Altucci L, Moncharmont B, Puca GA, Porcellini A, Avvedimento EV, Perillo B. Highlighting chromosome loops in DNA-picked chromatin. Epigenetics. 2011 6(8):979-86. DOI: 10.4161/epi.6.8.16060

Ianaro A, Tersigni M, Belardo G, Di Martino S, Napolitano M, Palmieri G, Sini M, De Maio A, Ombra M, Gentilcore G, Capone M, Ascierto M, Satriano RA, Farina B, Faraone-Mennella M, Ascierto PA, Ialenti A. NEMO-binding domain peptide inhibits proliferation of human melanoma cells. Cancer Lett. 2009 Feb 18;274(2):331-6
doi: 10.1016/j.canlet.2008.09.038

Ombra MN, Perillo B, Bertoni A, Cuozzo C, Sacchetti S, Sasso A, Chiariotti L, Malorni A, Abbondanza C, Avvedimento EV. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science. 2008 319(5860):202-6.
DOI: 10.1126/science.1147674

Moschella F, Ombra MN, Del Pozzo G, Guardiola J. Administration of different antigenic forms of altered peptide ligands derived from HIV-1 RTase influences their effects on T helper cell activation. Hum Immunol 2003 64(1):1-8. doi:10.1016/S0198-8859(02)00783-8

Ombra MN, Forabosco P, Casula S, Angius A, Maestrale G, Petretto E, Casu G, Colussi G, Usai E, Melis P, Pirastu M. Identification of a new candidate locus for uric acid nephrolithiasis. Am J Hum Genet 2001 68(5):1119-29. doi:10.1086/320105

Research Group

Research Area