Virginia Carbone

Virginia Carbone

Researcher

Direct: +39 0825 299211
Lab 1 +39 0825 299204
Lab 2 +39 0825 299205
FAX: +39 0825 781585
Email: virginia.carbone@isa.cnr.it

Short CV

Research Interests

Main research activity of Virginia Carbone is focused on the  development and application of advanced analytical methodologies based on mass spectrometry in Food Science and Human Health areas. In particular, she is involved in chemical and biological studies of food and medicinal plants with a special focus on the structural characterization of secondary metabolites belonging to different classes by integrating chromatographic techniques (High Performance Liquid Chromatography-HPLC) and detection methods such as UV spectroscopy and conventional (LC-MS), tandem (LC-MS/MS) and multicollision (LC-MS/MSn) mass spectrometry.

The aim of this research activity is the definition of molecular profiles useful for:

  • promotion of food products through the identification of molecules with specific biological activities of particular interest.
  • comparison of different cultivars and definition of geographical origin;
  • monitoring changes in the qualitative and quantitative profiles during ripening, industrial treatments or in plants subjected to different stress;
  • identification of specific biomarkers for the assessment of food authenticity and quality

 

Key Publications

Publications

  1. I. Tedesco, V. Carbone, C. Spagnuolo, P. Minasi, G.L. Russo “Identification and quantification of flavonoids from two southern italian cultivars of Allium cepa L., Tropea (Red Onion) and Montoro (Copper Onion), and their capacity to protect human erythrocytes from oxidative stress” J Agric Food Chem., 63(21), 5229-5238, 2015. PMID: 25965971
  2. L. F. Ciarmiello, M. F. Mazzeo, P. Minasi, A. Peluso, A. De Luca, P. Piccirillo, R. A. Siciliano, V. Carbone “Analysis of different European hazelnut (Corylus avellana L.) cultivars: authentication, phenotypic features, and phenolic profiles” J Agric Food Chem., 62(26), 6236-6246, 2014. PMID: 24927513
  3. G. Nocca, V. Carbone, A. Lupi, S. Rengo, G. Spagnuolo “HPLC analytical study of methacrylic monomers released from dental composite materials” in High-Performance Liquid Chromatography (HPLC) Principles, Practices and Procedures, Yuegang Zuo Editor, North Dartmouth (USA), Chapter 8, 193-205, 2014. ISBN 978-1-62948-858-5
  4. G. Nocca, G. Spagnuolo, A. Lupi, D. V. Rossetti, V. Carbone, S. Rengo, C. Desiderio “Identification of Adducts of 2-Hydroxyethyl Methacrylate with N-Acetylcysteine or Glutathione through Capillary Electrophoresis Analysis” in Capillary Electrophoresis: Fundamentals, Techniques and Applications, Nova Science Publishers, New York (USA), Chapter 5, 101-116, 2012. ISBN 978-1-62081-785-8
  5. G. Nocca, R. Ragno, V. Carbone, G. E. Martorana, D. V. Rossetti, G. Gambarini, B. Giardina, A. Lupi “Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis” Dental Mater, 27, e87–e98, 2011. PMID: 21371745
  6. A. Mari, I. Tedesco, A. Nappo, G. L. Russo, A. Malorni, V. Carbone “Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar” Food Chem, 123, 157-164, 2010.
  7. L. Campaner dos Santos, M. Aparecido da Silva, C. M. Rodrigues, V. Carbone, A. Napolitano, C. Bassarello, A. Mari, S. Piacente, C. Pizza and W. Vilegas “Characterization of Flavonoid and Naphthopyranone derivatives from Eriocaulon ligulatum using Liquid Chromatography Tandem Mass Spectrometry” Nat Prod Commun, 4 (12), 1651 – 1656, 2009. PMID: 20120100
  8. A. Benavides, A.. Napolitano, C. Bassarello, V. Carbone, P. Gazzerro, A. Malfitano, P. Saggese, M. Bifulco, S. Piacente, C. Pizza “Oxylipins from Dracontium loretenseJ Nat Prod., 72 (5), 813–817, 2009. PMID: 19341262
  9. W. Craig, P. Lenzi, N. Scotti, M. De Palma, P. Saggese, V. Carbone, N. Mcgrath Curran, A. M. Mage, P. Medgyesy, T. A. Kavanagh, P. J. Dix, S. Grillo, T. Cardi “Transplastomic tobacco plants expressing a fatty acid desaturase gene exhibit altered fatty acid profiles and improved cold tolerance” Transgenic Research, 17(5), 769-782, 2008. PMID: 18214708
  10. A. Napolitano, V. Carbone, P. Saggese, K. Takagaki, C. Pizza “Novel galactolipids from the leaves of Ipomoea batatas L.: characterization by liquid chromatography coupled with electrospray ionization-quadrupole time-of-flight tandem mass spectrometry” J. Agr. Food Chem., 55(25), 10289-10297, 2007. PMID: 17988089
  11. E. Aranda, I. García-Romera, J.A. Ocampo, V. Carbone , A. Mari , A. Malorni , F. Sannino, A. De Martino, R. Capasso “Chemical characterization and effects on Lepidium sativum of the native and bioremediated components of dry olive mill residue” Chemosphere, 69(2), 229-239, 2007.
  12. M. Sannomiya, L. Campaner dos Santos, V. Carbone, A. Napolitano, S. Piacente, C. Pizza, Alba R. M. Souza-Brito, W. Vilegas “Liquid chromatography/electrospray ionization tandem mass spectrometry profiling of compounds from the infusion of Byrsonima fagifolia NiedenzuRapid Commun Mass Spectrom, 21, 1393–1400, 2007. PMID: 17370245
  13. E. Aranda, I. García-Romera, J.A. Ocampo, V. Carbone, A. Malorni, F. Sannino, A. De Martino, R. Capasso “Reusing ethyl acetate and aqueous exhausted fractions of dry olive mill residues by saprobe fungi” Chemosphere, 66, 67-74, 2007.
  14. F. Facchiano, D. D’Arcangelo, K. Russo, V. Fogliano, C. Mennella, R. Ragone, G. Zambruno, V. Carbone, D. Ribatti, C. Peschle, M. C. Capogrossi, A. Facchiano “Glycated-FGF-2 is quickly produced in vitro upon low-millimolar glucose treatment and detected in vivo in diabetic mice” Mol Endocrinol., 20, 2806-2818, 2006. PMID: 16840537

Patents

Napolitano Assunta; Carbone Virginia; Saggese Paola; Pizza Cosimo; Takagaki Kinya “Galactolipids isolated from sweet potato leaves and foods containing them”

Patent Number WO 2008108001.

Kind A1

Date 12/09/2008

Application No WO 2007-JP54598

Date 02/03/2007

International Patent

Research Group

Proteomic and Biomolecular Mass Spectrometry Center (CeSMAProBio)

Research Area OMICS