Neuroprotective Role of Natural Polyphenols

SpagnuoloCNeuroprotective Role of Natural Polyphenols: a Look to the Potentiality of Elderberry Extracts

We are pleased to welcome Dr. Carmela Spagnuolo from the Institute of Food Sciences, National Research Council in Italy at the 10th World Congress on Polyphenols Applications: Porto Polyphenols 2016.

During this congress Dr. Spagnuolo will talk about Neuroprotective Role of Natural Polyphenols: a Look to the Potentiality of Elderberry Extracts.

Neurodegenerative diseases cause a progressive functional alteration of neuronal systems, resulting in a state of dementia which is considered one of the most common psychiatric disorders of the elderly. Polyphenols may behave as potential neuroprotective agents, since their ability to influence and modulate key cellular processes implicated in neurodegeneration. Several studies show the promising neuroprotective effects of herbal compounds (e.g., (-)-epigallocatechin-3-gallate, resveratrol, curcumin, quercetin and others) or extracts (e.g. tea polyphenols). Berries represent a rich source of flavonoids and among them, we showed that Sambucus nigra extract possesses elevated polyphenolic content and antioxidant capacity. Our results, obtained on human neuroblastoma cell line (IMR-32) differentiated into neuronal cells, indicate that Sambucus nigra extract protects these cells against oxidative damage acting pleiotropically on several antioxidant mechanisms.

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