Carmela Spagnuolo


Name: Carmela
Surname: Spagnuolo
Skill: Researcher
Phone: (Office) +39 0825 299 331
Phone: (Lab) +39 0825 299 261
Fax: +39 0825 299 641
CNR People WEB Site:
Keywords: bioactive compounds, polyphenols, oxidative stress, cancer, chemoprevention, neurodeprotection, pro-health
Curriculum EN: (click here to view it)

Researcher Activities


Dr. Spagnuolo works at the Institute of Food Sciences since 2007, first as fellow and from 1 July 2020 as a Researcher – III level, for the strategic area “Food Production and Nutrition”. Her general competence is in the field of cellular and molecular biology. Her research focuses mainly on the study of how natural compounds (extracts and pure molecules) exert, at the molecular level, a protective effect against degenerative diseases. In particular, she has studied the chemopreventive and adjuvant activity of selected phytochemicals, such as quercetin, paying attention to the molecular mechanisms triggered. She is also interested in the antioxidant and anti-inflammatory activities of polyphenols and food extracts in the prevention of diseases associated with aging, such as neurodegenerative diseases.

Key Publications


  • Tedesco I*, Spagnuolo C*, Bilotto S, Izzo AA, Borrelli F, Rigano D, Russo M, Tarricone F, Russo GL. Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops. Antioxidants (Basel). 2020 Dec 30;10(1):29.
  • Russo GL, Spagnuolo C, Russo M, Tedesco I, Moccia S, Cervellera C. Mechanisms of aging and potential role of selected polyphenols in extending healthspan. Biochem Pharmacol. 2020 Mar;173:113719
  • Spagnuolo C, Moccia S, Russo GL. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem. 2018 Jun 10;153:105-115.
  • Spagnuolo C, Flores G, Russo GL, Ruiz del Castillo ML. A phenolic extract obtained from methyl jasmonate treated strawberries enhances apoptosis in a human cervical cancer cell line. Nutr Cancer. 2016 Oct;68(7):1140-50.
  • Spagnuolo C, Napolitano M, Tedesco I, Moccia S, Russo GL. Neuroprotective role of natural polyphenols. Current Topic in Medicinal Chemistry. 2016;16(17):1943-50