Gianfranco Mamone


Name: Gianfranco
Surname: Mamone
Skill: Senior Researcher 
Phone: (Office) +39 0825 299 521
Phone: (Lab) +39 0825 299 218
Fax: +39 0825 299 218
CNR People WEB Site:
Curriculum EN: (click here to view it)

Researcher Activities

The activity of dr. Mamone is focused on the isolation and structural characterization of molecules and macromolecules with interest in food sciences, by means of advanced high performance separation techniques and mass spectrometry. More specifically, main part of the activity of Dr. Mamone is focused on the study of proteins under several aspects: 1. proteomics applied to the study of food related proteins; 2. proteolytic events in foods; 3. identification of bioactive sequences generated from food proteins (bioactive peptides); 4. characterization of post-translational modifications of proteins; 5. development of new methodologies in proteomics.

Key Publications

Mamone G, Nitride C, Picariello G, Addeo F, Ferranti P, Mackie AR. Tracking the fate of pasta (T. durum semolina) immunogenic proteins by in vitro simulated  digestion.

J Agric Food Chem. 2015 Feb 14. [

Epub ahead of print] PubMed PMID: 25682706.


Iacomino G, Fierro O, D’Auria S, Picariello G, Ferranti P, Liguori C, Addeo F, Mamone G. Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31-55.

J Agric Food Chem. 2013 Feb 6;61(5):1088-96.

doi: 10.1021/jf3045523. Epub 2013 Jan 27. PubMed PMID: 23298305.


Mamone G, Caira S, Garro G, Mauriello R, Nicolai MA, Picariello G, Calabrese MG, Ferranti P, Chianese L, Addeo P. Challenging the heterogeneity of casein by an IEF/MALDI-TOF “virtual 2D-like” approach.

Food Research Internation. 2013 Nov;54(1): 1263-1272




Mamone G, Picariello G, Addeo F, Ferranti P.

Proteomic analysis in allergy and intolerance to wheat products.

Expert Rev Proteomics. 2011 Feb;8(1):95-115.

doi: 10.1586/epr.10.98. Review. PubMed PMID: 21329430.


Mamone G, Picariello G, Ferranti P, Addeo F.

Hydroxyapatite affinity chromatography for the highly selective enrichment of mono- and multi-phosphorylated peptides in phosphoproteome analysis. Proteomics. 2010 Feb;10(3):380-93. doi: 10.1002/pmic.200800710. PubMed PMID: 19953538.


Mamone G, De Caro S, Di Luccia A, Addeo F, Ferranti P.

Proteomic-based analytical approach for the characterization of glutenin subunits in durum wheat.

J Mass Spectrom. 2009 Dec;44(12):1709-23.

doi: 10.1002/jms.1680. PubMed PMID: 19830788.


De Caro, S., Ferranti, P., Addeo, F., Mamone, G.

Isolation and characterization of Avenin-like protein type-B from durum wheat (2010)

Journal of Cereal Science, 52 (3), 426-431.

DOI: 10.1016/j.jcs.2010.07.005



Mamone G, Picariello G, Caira S, Addeo F, Ferranti P.

Analysis of food proteins and peptides by mass spectrometry-based techniques.

J Chromatogr A. 2009

Oct 23;1216(43):7130-42. doi: 10.1016/j.chroma.2009.07.052. Epub 2009 Aug 3.

Review. PubMed PMID: 19699482.


Mamone G, Ferranti P, Rossi M, Roepstorff P, Fierro O, Malorni A, Addeo F.

Identification of a peptide from alpha-gliadin resistant to digestive enzymes:

implications for celiac disease.

J Chromatogr B Analyt Technol Biomed Life Sci.2007 Aug 15;855(2):236-41.

Epub 2007 May 18. PubMed PMID: 17544966.


Mamone G, Addeo F, Chianese L, Di Luccia A, De Martino A, Nappo A, Formisano, A, De Vivo P, Ferranti P.

Characterization of wheat gliadin proteins by combined  two-dimensional gel electrophoresis and tandem mass spectrometry.

Proteomics. 2005 Jul;5(11):2859-65.

PMID: 15952231.

Gruppo di Ricerca

Gianfranco Mamone

Luigia Di Stasio, fellow

Ilaria Staliano, fellow


Area di Ricerca :