Giuseppe Iacomino

Name: Giuseppe
Surname: Iacomino
Skill: Researcher
Phone: (Office) +39 0825 299 431
Phone: (Lab) +39 0825 299 201
Fax: +39 0825 299 641
CNR People WEB Site:
Keywords: molecular and cell biology, microRNA, DNA, transcription, gut metabolism, food biotransformation, obesity-related disease

Research Activities 

Giuseppe Iacomino is a senior and staff scientist at the “Istituto di Scienze dell’Alimentazione” – Consiglio Nazionale delle Ricerche (CNR). He received a PhD in Biochemistry and specialises in Biochemistry and Clinical Chemistry. His main experience is in the fields of Biochemistry, Cell Biology, Molecular Biology, Cancer prevention, Cancer Biology, and Nutritional Biochemistry. He is currently an elected member of the ISA Institute’s Scientific Council. He teaches Medical Genetics at the University of Sannio (BN). He currently serves as Associate Editor for “Genes” MDPI.

Research has been focused, at the molecular level, on different aspects of food, from chemo-prevention to diet-related diseases. His main expertise is on epigenomics, gene expression control, the role of chromatin modifiers in affecting the transcriptional activity, on the cell cycle and apoptosis. In this respect, the downstream effects of nutrients with chromatin-modifying ability are emerging as fundamental aspects contributing to the response to food and individual nutrient intake. Scientific interests are also focused on the role of polyamines in governing the nuclear organization: our group firstly discovered that polyamines self-assemble in the cell nucleus and generate compounds referred to as nuclear aggregates of polyamines (NAPs) which interact with genomic DNA and regulate decisive aspects of DNA physiology, such as conformation, protection and packaging. Scientific interests also cover the valorisation of food and food products by studying the bio-accessibility, bio-transformation, and transport using models of simulated digestion and human intestinal cells. His recent research activity addressed the differential signature of microRNAs in obesity and metabolic diseases.

Key Publications

  • Giuseppe Iacomino, Fabio Lauria, Paola Russo, Antonella Venezia, Nunzia Iannaccone, Pasquale Marena, Wolfgang Ahrens, Stefaan De Henauw, Dénes Molnár, Gabriele Eiben, Ronja Foraita, Antje Hebestreit, Giannis Kourides, Luis A Moreno, Toomas Veidebaum, and Alfonso Siani. “The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study”
    Genes & Nutrition, 2021, 16, 10.
  •  Giuseppe Iacomino, Vera Rotondi Aufiero, Luigia Di Stasio, Stefania Picascia, Nunzia Iannaccone, Nicola Giardullo, Riccardo Troncone, Carmen Gianfrani, Gianfranco Mamone, Giuseppe Mazzarella
    “Triticum monococcum amylase trypsin inhibitors possess a reduced potential to elicit innate immune response in celiac patients compared to Triticum aestivum”
    Food Research International, 2021, 145, 110386. doi: 
  • Giuseppe Iacomino, Vera Rotondi Aufiero, Nunzia Iannaccone, Raffaele Melina, Nicola Giardullo, Giovanni De Chiara, Antonella Venezia, Fabio Silvio Taccone, Gaetano Iaquinto, Giuseppe Mazzarella
    “IBD: role of intestinal compartments in the mucosal immune response”.
    Immunobiology, 225 (2020) 151849
  • Giuseppe Iacomino, Paola Russo, Pasquale Marena, Fabio Lauria, Antonella Venezia, Wolfgang Ahrens, Stefaan De Henauw, Pasquale De Luca, Ronja Foraita, Kathrin Günther, Lauren Lissner, Dénes Molnár, Luis A Moreno, Michael Tornaritis, Toomas Veidebaum, and Alfonso Siani.
    “Circulating microRNAs expression profiles are associated with early childhood obesity: results of the I.Family Study”.
    Genes & Nutrition, 2019, 14:2.
  • Paola Pedata, Giulia Ricci, Livia Malorni, Antonella Venezia, Marcella Cammarota, Maria Grazia Volpe, Nunzia Iannaccone, Vincenzo Guida, Chiara Schirardi, Marco Romano, Giuseppe Iacomino.
    Intestinal response to titanium dioxide nanoparticles.
    Food Research International, 2018,
  • Giuseppe Iacomino & Alfonso Siani
    “Role of microRNAs in obesity and obesity-related diseases”
    Genes & nutrition, 2017, 12, 23
  • Iacomino G, Russo P,Stillitano I, Lauria F, Marena P, Ahrens W, Siani A
    “Circulating miRNAs are deregulated in prepubertal overweight/obese children: preliminary results of the IFamily Study”
    Genes & Nutrition 11 (1), 1, 2016         
  • Iacomino, Giuseppe; Fierro, Olga; D’Auria, Sabato; Picariello, Gianluca; Ferranti, Pasquale; liguori, claudia; Addeo, Francesco; Mamone, Gianfranco.
     “Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31-55”
    Agric. Food Chem., 2013, 61 (5), pp 1088–1096
  • Giuseppe Iacomino, Gianluca Picariello, Luciano D’Agostino.
    “DNA and nuclear aggregates of polyamines”
    Biochimica et Biophysica Acta 1823 (2012) 1745–1755
  • Giuseppe Iacomino, Gianluca Picariello, Francesca Sbrana, Aldo di Luccia, Roberto Raiteri, Luciano D’Agostino.
    “DNA is Wrapped by Nuclear Aggregates of Polyamines: The Imaging Evidence”
    Biomacromolecules  (2011), 12, 4, 1178–1186