Rosa Anna Siciliano


Name: Rosa
Surname: Siciliano
Skill: Senior Researcher
Phone: (Office) +39 0825 299 363
Phone: (Lab) +39 0825 299 151
Fax: +39 0825 299 641
CNR People WEB Site:
Keywords: proteomics, mass spectrometry, food proteins, probiotics, food microorganisms, food science
Curriculum EN: (click here to view it)

Researcher Activities

Development and application of methods based on mass spectrometry and proteomics for studies of relevant interest in food and life sciences

In particular, studies were carried out on the following topics:

  • Functional and comparative proteomics to investigate i) mechanisms underlying functional features of probiotic bacteria; ii) stress response processes in microorganisms of technological interest for food production or in pathogens; iii) adaptation to biotic or abiotic stress conditions in plants.
  • Development and application of innovative molecular profiling methodologies based on MALDI-TOF mass spectrometry, fast and reliable, for the identification of foodborne bacteria, to evaluate the authenticity of fresh and processed food products, in particular in the seafood sector.
  • Structural characterization of food proteins and their post-biosynthetic modifications (also originating from technological processes). Mass spectrometric approaches have been also applied to assess milk quality and to monitor technological processes aimed to abolish gluten toxicity for celiac patients

Key Publications

  • Siciliano R.A., Reale A., Mazzeo M.F., Morandi S., Silvetti T., Brasca M. Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals. Nutrients. (2021) 13, 1225.
  • Rossi S., Giordano D., Mazzeo M.F., Maurano F., Luongo D., Facchiano A., Siciliano R.A., Rossi M. Transamidation Down-Regulates Intestinal Immunity of Recombinant α-Gliadin in HLA-DQ8 Transgenic Mice. Int. J. Mol. Sci. (2021) 22, 7019.
  • Mazzeo M.F., Luongo D., Sashihara T., Rossi M., Siciliano R.A. Secretome Analysis of Mouse Dendritic Cells Interacting with a Probiotic Strain of Lactobacillus gasseri. Nutrients (2020) 12, 555.
  • Siciliano R.A., Mazzeo M.F., Ferretta A., Pacelli C., Rosato A., Papa F., Scacco S., Papa S., Cocco T., Lippolis R. Decreased amount of vimentin N-terminal truncated proteolytic products in parkin-mutant skin fibroblasts. Biochem. Biophys. Res. Commun. (2020) 521, 693-698.
  • Rosa L., Lepanto M.S., Cutone A., Siciliano R.A., Paesano R., Costi R., Musci G., Valenti P. Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders. Biometals (2020) 33, 159-168.
  • Siciliano R.A., Pannella G., Lippolis R., Ricciardi A., Mazzeo M.F., Zotta T. Impact of aerobic and respirative life-style on Lactobacillus casei N87 proteome.  Int. J. Food Microbiol. (2019) 298, 51-62.
  • Siciliano R.A., Lippolis R., Mazzeo M.F. Proteomics for the Investigation of Surface-Exposed Proteins in Probiotics. Front. Nutr. (2019) 6, 52.
  • Siciliano R.A., Uzzau S., Mazzeo M.F. Proteomics for Studying Foodborne Microorganisms and Their Impact on Food Quality and Human Health (Editorial). Front Nutr. (2019) 6, 104.
  • Mazzeo M.F., Cacace G., Iovieno P., Massarelli I., Grillo S., Siciliano R.A. Response mechanisms induced by exposure to high temperature in anthers from thermo-tolerant and thermo-sensitive tomato plants: A proteomic perspective. PLoS One (2018) 13, e0201027.
  • Mazzeo M.F., Di Stasio L., D’Ambrosio C., Arena S., Scaloni A., Corneti S., Ceriotti A., Tuberosa R., Siciliano R.A., Picariello G., Mamone G. Identification of Early Represented Gluten Proteins during Durum Wheat Grain Development. J. Agric. Food Chem. (2017) 65, 3242-3250.