Angelo Facchiano


Name: Angelo
Surname: Facchiano
Skill: Research Director
Phone: (Office) +39 0825 299 625
Phone: (Lab) +39 0825 299 651
Fax: +39 0825 299 641
CNR People WEB Site:
Keywords: bioinformatics, molecular interaction, protein structure and function
Curriculum EN: (click here to view it)

Researcher Activities

Development and application of bioinformatics tools for the study of food-related diseases, molecular mechanisms of the effect of food components on health

Key Publications

  • Giordano D, De Masi L, Argenio MA, Facchiano A. (2021)Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor.
    Biomedicines, 9(8):1038. doi:10.3390/biomedicines9081038. PMID: 34440241.
  • Marabotti A, Del Prete E, Scafuri B, Facchiano A (2021)
    Performance of Web tools for predicting changes in protein stability caused by mutations.
    BMC Bioinformatics 22(Suppl 7):345. doi: 10.1186/s12859-021-04238-w PMID: 34225665.
  • Giordano D, Facchiano A, D’Auria S, Loreto F. (2021).
    A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences.
    Elife 2021 Jun 23;10:e66741. doi: 10.7554/eLife.66741. PMID: 34161230.
  • Dotolo S, Cervellera C, Russo M, Russo GL, Facchiano A. (2021)
    Virtual Screening of Natural Compounds as Potential PI 3 K-AKT1 Signaling Pathway Inhibitors and Experimental Validation.
    Molecules 2021 Jan 18;26(2):492. doi: 10.3390/molecules26020492. PMID: 33477701
  • Scafuri B, Bontempo P, Altucci L, De Masi L, Facchiano A. (2020)
    Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding.
    Biomedicines 2020 Dec 4;8(12):E568. doi: 10.3390/biomedicines8120568. PMID: 33291755
  • Marabotti A, Scafuri B, Facchiano A. (2020)
    Predicting the stability of mutant proteins by computational approaches: an overview.
    Brief Bioinform. 2020 Jun 3:bbaa074. doi: 10.1093/bib/bbaa074. Online ahead of print. PMID: 32496523
  • Giordano D, Facchiano A. (2019)
    Classification of microbial transglutaminases by evaluation of evolution trees, sequence motifs, secondary structure topology and conservation of potential catalytic residues.
    Biochem Biophys Res Commun. 2019, 509(2), 506-513. doi: 10.1016/j.bbrc.2018.12.121. PMID: 30595384
    Corrigendum: Biochem Biophys Res Commun. 2019 Mar 26;511(1):205. doi: 10.1016/j.bbrc.2019.02.058. PMID: 30777328
  • De Masi L, Castaldo D, Pignone D, Servillo L, Facchiano A. (2017)
    Experimental Evidence and In Silico Identification of Tryptophan Decarboxylase in Citrus Genus.
    Molecules 2017 Feb 11;22(2). pii: E272. doi: 10.3390/molecules22020272.
    PMID: 27808487
  • Scafuri B, Marabotti A, Carbone V, Minasi P, Dotolo S, Facchiano A. (2016)
    A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer.
    Sci Rep. 2016 Sep 2;6:32516. doi: 10.1038/srep32516.
    PMID: 27587238
  • Romano P, Profumo A, Rocco M, Mangerini R, Ferri F, Facchiano A. (2016)
    Geena 2, improved automated analysis of MALDI/TOF mass spectra.
    BMC Bioinformatics 2016 Mar 2;17 Suppl 4:61. doi: 10.1186/s12859-016-0911-2. PMID: 26961516