Carmela Spagnuolo


Carmela Spagnuolo


Direct: +39 0825 299261
FAX: +39 0825 781585

Short CV

Research Interests

Carmela Spagnuolo obtained her degree in 2007 in Biological Sciences (University of Sannio, Benevento, Italy) and in 2011 she completed Doctorate Programme in Medical Oncology, Surgery and Clinical Immunology (Second University of Naples, Italy).

In 2010/11 she moved abroad in a highly qualified Laboratory, as Fondation Recherche sur le Cancer et les Maladies du Sang Laboratoire de Biologie Moleculaire et Cellulaire du Cancer (LBMCC) in Luxembourg, directed by Dr. Marc Diederich, where she works on molecular mechanism of natural compound. In 2013 she attended the laboratories of Kosuke Yusa in Wellcome Trust Sanger Institute Genome Campus, Hinxton, Cambridgeshire, United Kingdom, learning the techniques to reprogram and differentiate human induced pluripotent stem cells (hiPSCs) and to engineer them.

Her interest is mainly focused on the study of natural compounds (food extracts and pure molecules) with healthy effects on humans.

In details, she is studying the potential chemopreventive and therapeutic activities of selected phytochemicals, such as quercetin, and their ability to sensitize malignant cell lines to apoptotic stimuli and chemotherapeutic drugs. A careful attention is paid to the molecular mechanisms triggered by these compounds. She is interested to the antioxidant activity of polyphenols and food extracts and their protective effect against stress induced in human erythrocytes. Moreover, she leads a research project on the neuroprotective effects of natural compounds in cellular models.

Her generalist expertise is in the field of cellular and molecular biology.

Key Publications

Selected publications (2010-2015)

Spagnuolo C,Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R, Nabavi SM.
Genistein and cancer: current status, challenges, and future directions.
AdvNutr. 2015 Jul 15;6(4):408-19. doi: 10.3945/an.114.008052.
PMID: 26178025

Tedesco I*, Carbone V*, Spagnuolo C*, Minasi P, Russo GL.
Identification and Quantification of Flavonoids from Two Southern Italian Cultivars of Allium cepa L., Tropea (Red Onion) and Montoro (Copper Onion), and Their Capacity to Protect Human Erythrocytes from Oxidative Stress.
J Agric Food Chem. 2015 Jun 3;63(21):5229-38. doi: 10.1021/acs.jafc.5b01206.

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.
Broad targeting of resistance to apoptosis in cancer.
Semin Cancer Biol. 2015 Apr 28. pii: S1044-579X(15)00016-4. doi: 10.1016/j.semcancer.2015.03.001.

Russo GL, Russo M, Spagnuolo C.
The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia.
FoodFunct. 2014 Oct;5(10):2393-401. doi: 10.1039/c4fo00413b.
PMID: 25096193

Spagnuolo C, Tedesco I, Volpe MG, Bilotto S, Russo M, Russo GL
Cytotoxic Properties of Lyophilized Beers in a Malignant Cell Line
Food and Nutrition Sciences 2014, 5:45-51 (2014).

Russo GL, Russo M,Spagnuolo C, Tedesco I, Bilotto S, Iannitti R, Palumbo R.
Quercetin: a pleiotropic kinase inhibitor against cancer.
Cancer Treat Res. 2014;159:185-205. doi: 10.1007/978-3-642-38007-5_11.

Tedesco I, Russo M, Bilotto S,Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L,RussoGL.
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line.
Food ChemToxicol. 2013 Oct;60:377-84. doi: 10.1016/j.fct.2013.07.078.
PMID: 3933363

Russo M*,Spagnuolo C*, Volpe S, Tedesco I, Bilotto S,Russo GL.
ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation.
BiochemPharmacol. 2013 Apr 1;85(7):927-36. doi: 10.1016/j.bcp.2013.01.011.

Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B,Russo GL.
Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia.
Ann N Y Acad Sci. 2012 Jul;1259:95-103. doi: 10.1111/j.1749-6632.2012.06599.x.

Tedesco I*, Spagnuolo C*,Russo M, Iannitti R, Nappo A, Russo GL.
Protective Effect of γ-Irradiation Against Hypochlorous Acid-Induced Haemolysis in Human Erythrocytes.
Dose Response. 2012 Nov 16;11(3):401-12. doi: 10.2203/dose-response.12-025.

Russo M*,Spagnuolo C*, Tedesco I, Bilotto S,Russo GL.
The flavonoid quercetin in disease prevention and therapy: facts and fancies.
BiochemPharmacol. 2012 Jan 1;83(1):6-15. doi: 10.1016/j.bcp.2011.08.010.

Spagnuolo C, Cerella C,Russo M, Chateauvieux S, Diederich M, Russo GL
Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.
Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.

Russo M,Spagnuolo C, Volpe S, Mupo A, Tedesco I,Russo GL.
Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients.Br J Cancer. 2010 Aug 24;103(5):642-8. doi: 10.1038/sj.bjc.6605794.

Research Group


– Gian Luigi Russo (Senior Scientist)

– Idolo Tedesco (Research Assistant, M.Sc. in Science) 

– Maria Russo (Research Assistant, M.Sc. in Science) 

– Stefania Bilotto (PostDoc) 

– Stefania Moccia (PhD student)

– Maria Filomena Conte (undergraduate student) 

– Francesco Messano (undergraduate student)

– Mariangela Basile (undergraduate student)

– Vincenza Russo (undergraduate student)