Direct: +39 0825 299261
Carmela Spagnuolo obtained her degree in 2007 in Biological Sciences (University of Sannio, Benevento, Italy) and in 2011 she completed Doctorate Programme in Medical Oncology, Surgery and Clinical Immunology (Second University of Naples, Italy).
In 2010/11 she moved abroad in a highly qualified Laboratory, as Fondation Recherche sur le Cancer et les Maladies du Sang Laboratoire de Biologie Moleculaire et Cellulaire du Cancer (LBMCC) in Luxembourg, directed by Dr. Marc Diederich, where she works on molecular mechanism of natural compound. In 2013 she attended the laboratories of Kosuke Yusa in Wellcome Trust Sanger Institute Genome Campus, Hinxton, Cambridgeshire, United Kingdom, learning the techniques to reprogram and differentiate human induced pluripotent stem cells (hiPSCs) and to engineer them.
Her interest is mainly focused on the study of natural compounds (food extracts and pure molecules) with healthy effects on humans.
In details, she is studying the potential chemopreventive and therapeutic activities of selected phytochemicals, such as quercetin, and their ability to sensitize malignant cell lines to apoptotic stimuli and chemotherapeutic drugs. A careful attention is paid to the molecular mechanisms triggered by these compounds. She is interested to the antioxidant activity of polyphenols and food extracts and their protective effect against stress induced in human erythrocytes. Moreover, she leads a research project on the neuroprotective effects of natural compounds in cellular models.
Her generalist expertise is in the field of cellular and molecular biology.
Selected publications (2010-2015)
Spagnuolo C,Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R, Nabavi SM.
Tedesco I*, Carbone V*, Spagnuolo C*, Minasi P, Russo GL.
Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.
Russo GL, Russo M, Spagnuolo C.
Spagnuolo C, Tedesco I, Volpe MG, Bilotto S, Russo M, Russo GL
Russo GL, Russo M,Spagnuolo C, Tedesco I, Bilotto S, Iannitti R, Palumbo R.
Tedesco I, Russo M, Bilotto S,Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L,RussoGL.
Russo M*,Spagnuolo C*, Volpe S, Tedesco I, Bilotto S,Russo GL.
Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B,Russo GL.
Tedesco I*, Spagnuolo C*,Russo M, Iannitti R, Nappo A, Russo GL.
Russo M*,Spagnuolo C*, Tedesco I, Bilotto S,Russo GL.
Spagnuolo C, Cerella C,Russo M, Chateauvieux S, Diederich M, Russo GL
Russo M,Spagnuolo C, Volpe S, Mupo A, Tedesco I,Russo GL.
– Gian Luigi Russo (Senior Scientist)
– Idolo Tedesco (Research Assistant, M.Sc. in Science)
– Maria Russo (Research Assistant, M.Sc. in Science)
– Stefania Bilotto (PostDoc)
– Stefania Moccia (PhD student)
– Maria Filomena Conte (undergraduate student)
– Francesco Messano (undergraduate student)
– Mariangela Basile (undergraduate student)
– Vincenza Russo (undergraduate student)