Olga Fierro

Donna

Name: Olga

Surname: Fierro

Skill: Researcher
Phone: (Office) +39 0825 299 412
Phone: (Lab) +39 0825 299 171
Fax: +39 0825 299 641
e-mail: olga.fierro@isa.cnr.it
 
CNR People WEB Site: http://www.cnr.it/people/olga.fierro
Keywords: Peptides; Peptide analogs; Biological Peptides; Food; Drug Discovery
Curriculum EN: (click here to view it)

Researcher Activities

 

Laboratory of Dr. Fierro focuses on the study of chemistry and biology of bioactive peptides and synthetic analogs in food and pharmacological field. This study encompasses solid phase chemistry, molecular design, structure analysis, combinatorial synthesis and biological investigations. Targets are selected on the basis of novel molecular architecture, important biological activity and interesting mechanism of action. In addition, she is interested in the development of new and/or improved chemical methods (via SPPS or classical organic liquid-phase synthesis) for the synthesis of organic compounds of biological importance.

Key Publications

  • Camarca, A., Auricchio, R., Picascia, S., Fierro, O., Maglio, M., Miele, E., Malamisura, B., Greco, L., Troncone, R., Gianfrani, C.: “Gliadin-reactive T cells in Italian children from prevent CD cohort at high risk of celiac disease”; Pediatric Allergy and Immunology, 28 (4), 2017, 362-369.
  • Iacomino, G., Di Stasio, L., Fierro, O., Picariello, G., Venezia, A., Gazza, L., Ferranti, P., Mamone, G.: “Protective effects of ID331 Triticum monococcum gliadin on in vitro models of the intestinal epithelium”; Food Chemistry, 212, 2016, 537-542.
  • Picariello G., Iacomino G., Mamone, G., Ferranti P., Fierro O., Gianfrani C., Di Luccia A., Addeo F.: “Transport across Caco-2 monolayers of peptides arising from in vitro digestion of bovine milk proteins”; Food Chemistry, 139, 1-4, 2013, 203-212.
  • Picariello G., Sacchi R., Fierro O., Melck D., Romano R., Paduano A., Motta A., Addeo F.: “High resolution C-13 NMR detection of short- and medium-chain synthetic triacylglycerols used in butterfat adulteration”; European Journal of Lipid Science and Technology, 115, 8, 2013, 858-864.
  • Iacomino G., Fierro O., D’Auria S., Picariello G., Ferranti P., Liguori C., Addeo F., Mamone G.: “Structural analysis and caco-2 cell permeability of the celiac-toxic a-gliadin peptide 31-55”, Journal of Agricultural and Food Chemistry, 61, 5, 2013, 1088-1096.
  • De Laurentiis A., Gaspari M., Palmieri C., Falcone C., Iaccino E., Fiume G., Massa O., Masullo M., Tuccillo F.M., Roveda L., Prati U., Fierro O., et al.: “Mass spectrometry-based identification of the tumor antigen UN1 as the transmembrane CD43 sialoglycoprotein”, Molecular & Cellular Proteomics, 10, 5, 2011, Special Issue.
  • Pinto G., Caira S., Cuollo M., Lilla, S., Fierro O., Addeo F.: “Hydroxyapatite as a concentrating probe for phosphoproteomic analyses”, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 878, 28, 2010, 2669-2678.
  • Palmieri C., Falcone C., Iaccino E., Tuccillo F.M., Gaspari M., Trimboli F., De Laurentiis A., Luberto L., Pontoriero M., Pisano A., Vecchio E., Fierro O., et al.: “In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder”, Blood, 116, 2, 2010, 226-238.
  • Cuollo M., Caira S., Fierro O., Pinto G., Picariello G., Addeo F.: “Toward milk speciation through the monitoring of casein proteotypic peptides”, Rapid Communications in Mass Spectrometry, 24, 11, 2010, 1687-1696.
  • Picariello G., Ferranti P., Fierro O., Mamone G., Caira S., Di Luccia A., Monica S., Addeo F.: “Peptides surviving the simulated gastrointestinal digestion of milk proteins: biological and toxicological implications”, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 878, 3-4, 2009, 295-308.