Giuseppe Iacomino

Giuseppe Iacomino

Researcher

Direct: +39 0825 299431
Lab: +39 0825 299201/206
FAX: +39 0825 299431
Email: giuseppe.iacomino@isa.cnr.it

Short CV

Research Interests

Giuseppe Iacomino is a senior and staff scientist at Istituto di Scienze dell’AlimentazioneConsiglio Nazionale delle Ricerche (CNR). In 1989 he got his Laurea degree cum laude in Biological Science at University of Naples. From 1988 to 1990 he worked in the laboratories of Prof. Zappia (Biochemistry, Faculty of Medicine – University of Naples), and from 1991 to 1997 in the laboratories of Prof. Cascino (Molecular Biology, Faculty of Medicine – University of Naples). He has a Ph.D in Biochemistry and is specialised in Biochemistry and Clinical Chemistry. G. Iacomino has over 20 years of experience in the fields of Biochemistry, Cell Biology, Molecular Biology, Cancer prevention, Cancer Biology, and Nutritional Biochemistry.

His research has focused, at molecular level, on different aspects of food, from chemo-prevention to diet-related diseases.

His main expertise is on epigenomics, on gene expression control, on the role of chromatin modifiers in affecting the transcriptional activity, on the cell cycle and apoptosis. In this respect, the downstream effects of nutrients with chromatin modifying ability are emerging as fundamental aspects contributing to the response to food and individual nutrients intake. Scientific interests are also focused on the role of polyamines in governing the nuclear organization: we firstly found that polyamines self-assemble in the cell nucleus and generate compounds referred to as nuclear aggregates of polyamines (NAPs) which interact with genomic DNA and regulate decisive aspects of DNA physiology, such as conformation, protection and packaging. His recent research activity is also focused on the differential signature of microRNAs in obesity and obesity onset.

Moreover, scientific interests cover the valorization of food and food products influencing consumer health by studying the bio-accessibility, bio-transformation, and transport using models of simulated digestion and human intestinal cells.

He regularly reviews scientific manuscripts for international journals in the fields of cell and molecular biology, nutritional biochemistry, food related disorders, and grant applications. He regularly presents his research activity at meetings and seminars.

 

Key Publications

Natural Polymer Genomics: Phosphate-Induced Self-Assembly of Polyamines

The Encyclopedia of Biomedical Polymers & Polymeric Biomaterials.

Picariello, Gianluca; Iacomino Giuseppe, D’Agostino Luciano.

CRC Press .Taylor &  Francis 2015

http://www.crcpress.com/product/isbn/9781439898796

 

Giuseppe Iacomino, Gianluca Picariello, Ilaria Stillitano, Luciano D’Agostino

“Polyamines and DNA integrity: role of Nuclear Aggregates of Polyamines in a radiation-induced DNA damage model”

The International Journal of Biochemistry & Cell Biology, 47 (2014) 11– 19

http://dx.doi.org/10.1016/j.biocel.2013.11.007

 

Iacomino Giuseppe, Marano Angela, Stillitano Ilaria, Rotondi Aufiero Vera, Iaquinto Gaetano, Giardullo Nicola, Troncone Riccardo, Auricchio Salvatore, and Mazzarella Giuseppe

“Cytokine profile within the small intestinal compartments of celiac patients by laser capture microdissection”

Submitted 2014

 

Iacomino, Giuseppe; Fierro, Olga; D’Auria, Sabato; Picariello, Gianluca; Ferranti, Pasquale; liguori, claudia; Addeo, Francesco; Mamone, Gianfranco.

“Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31-55″

J. Agric. Food Chem., 2013, 61 (5), pp 1088–1096

http://pubs.acs.org/doi/abs/10.1021/jf3045523

 

Giuseppe Iacomino, Gianluca Picariello, Luciano D’Agostino.

“DNA and nuclear aggregates of polyamines”

Biochimica et Biophysica Acta 1823 (2012) 1745–1755

http://dx.doi.org/10.1016/j.bbamcr.2012.05.033

 

Giuseppe Iacomino, Gianluca Picariello, Francesca Sbrana, Aldo di Luccia, Roberto Raiteri, Luciano D’Agostino.

“DNA is Wrapped by Nuclear Aggregates of Polyamines”

Biomacromolecules  (2011)

http://pubs.acs.org/doi/ipdf/10.1021/bm101478j

 

Giuseppe Iacomino, Maria Cristina Medici and Gian Luigi Russo

“Valproic Acid Sensitizes K562 Erythroleukemia Cells to TRAIL/Apo2L-induced Apoptosis.”

Anticancer Research, 28: 855-864 (2008)

http://ar.iiarjournals.org/content/28/2A/855.full.pdf+html

 

G. Iacomino, M.C. Medici, D. Napoli, and G.L. Russo.

“Effects of Histone Deacetylase Inhibitors on p55CDC/Cdc20 Expression in HT29 Cell Line,”

Journal of Cellular Biochemistry, 2006, 99(4):1122-31

http://onlinelibrary.wiley.com/doi/10.1002/jcb.21014/abstract

 

Maria Russo, Rosanna Palumbo, Annalisa Mupo, Mariarosaria Tosto, Giuseppe Iacomino, Annamaria Scognamiglio, Idolo Tedesco, Giovanni Galano and Gian Luigi Russo.

“Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase C

Oncogene (2003) 22, 3330–3342

http://www.nature.com/onc/journal/v22/n21/abs/1206493a.html

 

Giuseppe Iacomino, Mario Felice Tecce, Claudia Grimaldi, Mariarosaria Tosto, and Gian Luigi Russo. Transcriptional Response of a Human Colon Adenocarcinoma Cell Line to Sodium Butyrate”

B.B.R.C., (2001), 285(5):1280-9

http://dx.doi.org/10.1006/bbrc.2001.5323

 

Mariarosaria Santillo, Paolo Mondola, Rosalba Serù, Tiziana Annella, Silvana Cassano, Ilaria Ciullo, Mario F. Tecce, Giuseppe Iacomino, Simona Damiano, Giovanni Cuda, Roberto Paternò, Valeria Martignetti, Evelina Mele, Antonio Feliciello, and Enrico V. Avvedimento.

“Opposing functions of Ki- and Ha-Ras genes in the regulation of redox signals”

Current Biology, (2001), 11 (8), 614-9

http://dx.doi.org/10.1016/S0960-9822(01)00159-2

 

Research Group

Molecular & Cell Biology (MCB) Lab

 

HEALTH

Collaborators

Ilaria Stilitano    contratto

Ilenia Gavitone Undergraduate Student

Tania Nero Undergraduate Student