Mauro Rossi

Research director
and Section Head

Direct: +39 0825 299308
Lab +39 0825 299161
Email: mauro.rossi@isa.cnr.it

Short CV

Research Interests

Mauro Rossi has over 20 years of experience in the field of the biochemistry and immunology of the small intestine. Section Editor of International Reviews of Immunology (INFORMA Healthcare, London UK). In 1985 he obtained a degree with honors in Biological Sciences at the University of Naples and then he specialised in General Pathology. From 1989 to 1994 he worked in the laboratories of Proff. Auricchio (University “Federico II” of Naples), Noren (Panum Institute, Copenhagen), Semenza (ETH, Zurich) on the biosynthesis of intestinal disaccharidases and lactose intolerance (adult-type hypolactasia). In 1995 he worked in the laboratory of Prof. Londei (Kennedy Institute of Rheumatology, London) on the cellular and molecular aspects of antigen-specific T cell activation. His recent research has focused on the immunology of the small intestine, mainly on the mechanisms of tolerance to food antigens and on the development of microbiological and enzymatic strategies to down-regulate the intestinal hypersensitivity to wheat gluten.

Statements by Ajinomoto and Dr. Rossi on Celiac Disease and tTG:https://www.transglutaminase.com/celiac-disease-tg/can-people-celiac-disease-eat-other-non-wheat-cross-linked-foods

 

Key Publications

  • Rossi M,  Maiuri L, Fusco MI, Salvati VM, Fuccio A, Auricchio S, Mantei N, Zecca L, Gloor SM, Semenza G. Lactase persistence versus decline in human adults: multifactorial  events are involved in down regulation after weaning. Gastroenterology 1997; 112: 1506-1514.
  • Senger S, Maurano F, Mazzeo MF, Gaita M, Fierro O, David CS, Troncone R, Auricchio S, Siciliano RA, Rossi M. Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 tg mice following oral immunisation. Journal of Immunology, 2005; 175: 8087-8095.
  • Enattah NS, Trudeau A, Pimenoff V, Maiuri L, Auricchio S, Greco L, Rossi M, Lentze M, Seo JK, Rahgozar S, Khalil I, Alifrangis M, Natah S, Groop L, Shaat N, Kozlov A, Verschubskaya G, Comas D, Bulaeva K, Mehdi SQ, Terwilliger JD, Sahi T, Savilahti E, Perola M, Sajantila A, Järvelä I, Peltonen L. Evidence for still ongoing convergence evolution of the lactase persistence T-13910 alleles in humans. American Journal of Human Genetics 2007 81(3):615-25.
  • Gianfrani C, Siciliano RA, Facchiano AM, Camarca A, Mazzeo MF, Costantini S, Salvati VM, Maurano F, Mazzarella G, Iaquinto G, Rossi M. Transamidation inhibits the intestinal immune response to gliadin in vitro,Gastroenterology 2007;133:780–789.
  • Bergamo P, Maurano F, Mazzarella G, Iaquinto G, Vocca I, Rivelli AR, De Falco E, Gianfrani C, Rossi M. Immunological evaluation of the alcohol-soluble protein fraction from gluten-free grains in relation to celiac disease. Molecular Nutrition & Food Research 2011 Aug;55(8):1266-70.
  • Lombardi E, Bergamo P, Maurano F, Bozzella G, Luongo D, Mazzarella G, Rotondi Aufiero V, Iaquinto G, Rossi M. Selective inhibition of the gliadin-specific, cell-mediated immune response by transamidation with microbial transglutaminase. Journal of Leukocyte Biology 2013;93(4):479-88.
  • Mazzeo MF; Bonavita R; Maurano F; Bergamo P; Siciliano RA; Rossi M. Biochemical modifications of gliadins induced by microbial transglutaminase on wheat flour, Biochimica et Biophysica Acta-General Subjects 2013 Jul 25;1830(11):5166-5174.
  • Luongo D, Miyamoto J, Bergamo P, Nazzaro F, Baruzzi F, Sashihara T, Tanabe S, Rossi M. Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri. BMC Microbiology, 2013 Dec 23;13(1):298.
  • Mazzarella G, Bergamo P, Maurano F, Luongo D, Aufiero VR,Bozzella G, Palmieri G, Troncone R, Auricchio S, David C, Rossi M. Gliadin intake alters the small intestinal mucosa in indomethacin treated HLA-DQ8 transgenic mice. American Journal of  Physiology Gastrointestinal Liver Physiology. 2014 Aug 1;307(3):G302-12.
  • Rossi M. Vaccination and other antigen-specific immunomodulatory strategies in Celiac Disease. Digestive Diseases 2015, 33(2):282-9.
  • Moscaritolo S, Treppiccione L, Ottombrino A, Rossi M. Effects of Two-Step Transamidation of Wheat Semolina on the Technological Properties of Gluten. Foods 2016, 5, 49; doi:10.3390/foods5030049
  • Treppiccione L, Ottombrino A, Luongo D, Maurano F, Manteca Á, Lombó F, Rossi M. Development of gluten with immunomodulatory properties using mTG-active food grade supernatants from Streptomyces mobaraensiscultures. Journal of Functional Foods, 2017; 34:390-397.
  • Luongo D, Treppiccione L, Sorrentino A, Ferrocino I, Turroni S, Gatti M, Di Cagno R, Sanz Y, Rossi M. Immune-modulating effects in mouse dendritic cells of lactobacilli and bifidobacteria isolated from individuals following omnivorous, vegetarian and vegan diets. Cytokine, 2017; 97:141-148.
  • Luongo D, Bonavita R, Rossi S, Rotondi Aufiero V, Feliciello N R, Maurano F, Iaquinto G, Mazzarella G, Rossi M. Tailoring the immune response to wheat gliadin by enzymatic transamidation. Cytokine 2019; 117: 23-29.

Research Group

Section Head of the Immunobiology Unit (ISA Research Area: FOOD). Our mission is to undertake research into the cellular and molecular aspects of intestinal physiology and thereby establish food-grade biotechnological approaches to improve human wellness. The final goal is the development of functional and novel foods.