Name: Mauro

Surname: Rossi

Skill: Research Director

Phone: (Office) +39 0825 299 371

Phone: (Lab) +39 0825 299 371

Fax: +39 0825 299 641

e-mail: mauro.rossi@isa.cnr.it

Keywords: gluten, probiotics, functional food, mucosal immunology

Curriculum EN: (click here to view it)

Researcher Activities

My recent research has been focused on the mechanisms of tolerance to food antigens and on the development of microbiological and enzymatic strategies to down-regulate the intestinal hypersensitivity to wheat gluten. I am also involved in basic and applied research on probiotics. My best finding is the possibility of carrying out an enzymatic treatment on wheat flour/semolina to detoxify the gluten for people affected by Coeliac Disease. The methodology developed is the subject of an international patent application that was granted in EU, Canada and USA.

Statements by Ajinomoto and Dr. Rossi on Celiac Disease and tTG:https://www.transglutaminase.com/celiac-disease-tg/can-people-celiac-disease-eat-other-non-wheat-cross-linked-foods

Expertise in Glutens:https://expertscape.com/au/glutens/Rossi%2C+Mauro

Key Publications

• Rossi M, Maiuri L, Fusco MI, Salvati VM, Fuccio A, Auricchio S, Mantei N, Zecca L, Gloor SM,
  Semenza G. Lactase persistence versus decline in human adults: multifactorial events are involved
  in down regulation after weaning. Gastroenterology 1997; 112: 1506-1514.
• Harvey CB, Hollox EJ, Poulter M, Wang Y, Rossi M, Auricchio S, Iqbal TH, Cooper B, Barton R,
  Sarner M, Korpela R, Swallow DM. Lactase haplotype frequencies in caucasians: association with
  the lactase persistence/non-persitence polymorphism. Annals of Human Genetics 1998; 62: 215-223.
• Senger S, Maurano F, Mazzeo MF, Gaita M, Fierro O, David CS, Troncone R, Auricchio S, Siciliano
  RA, Rossi M. Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 tg mice
  following oral immunisation. Journal of Immunology, 2005; 175: 8087-8095.
• Bergamo P, Luongo D, Maurano F, Mazzarella G, Stefanile R, Rossi M. Conjugated linoleic acid
  enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Fas(lpr) mice. Journal
  of Lipid Research 2006 Nov;47(11):2382-91.
• Gianfrani C, Siciliano RA, Facchiano AM, Camarca A, Mazzeo MF, Costantini S, Salvati VM,
  Maurano F, Mazzarella G, Iaquinto G, Rossi M. Transamidation inhibits the intestinal immune
  response to gliadin in vitro, Gastroenterology 2007;133:780–789.
• Luongo D, Miyamoto J, Bergamo P, Nazzaro F, Baruzzi F, Sashihara T, Tanabe S, Rossi M.
  Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri.
  BMC Microbiology, 2013 Dec 23;13(1):298.
• Mazzarella G, Bergamo P, Maurano F, Luongo D, Aufiero VR,Bozzella G, Palmieri G, Troncone R,
  Auricchio S, David C, Rossi M. Gliadin intake alters the small intestinal mucosa in indomethacin
  treated HLA-DQ8 transgenic mice. American Journal of Physiology Gastrointestinal Liver
  Physiology. 2014 Aug 1;307(3):G302-12.
• Treppiccione L, Ottombrino A, Luongo D, Maurano F, Manteca Á, Lombó F, Rossi M. Development
  of gluten with immunomodulatory properties using mTG-active food grade supernatants from
  Streptomyces mobaraensis cultures. Journal of Functional Foods, 2017; 34:390-397.
• Rossi S, Giordano D, Mazzeo MF, Maurano F, Luongo D, Facchiano A, Siciliano RA, Rossi M.
  Transamidation down-regulates intestinal immunity of recombinant a-gliadin in HLA-DQ8
  transgenic mice. International Journal of Molecular Sciences, 2021, 22, 7019.

Biotechnological Strategies for the Treatment of Gluten Intolerance