{"id":4038,"date":"2015-07-01T13:51:49","date_gmt":"2015-07-01T13:51:49","guid":{"rendered":"http:\/\/lserver.isa.cnr.it\/web\/?page_id=4038"},"modified":"2023-10-23T14:40:40","modified_gmt":"2023-10-23T14:40:40","slug":"antonio-varriale-2","status":"publish","type":"page","link":"https:\/\/www.isa.cnr.it\/web\/?page_id=4038","title":{"rendered":"Antonio Varriale"},"content":{"rendered":"

\"\"<\/h2>\n
Name: <\/strong>Antonio\r\n<\/pre>\n
Surname: <\/strong>Varriale\r\n<\/pre>\n
Skill<\/b>: Senior Researcher<\/pre>\n
Phone:<\/strong> (Office) +39 0825 299 101<\/pre>\n
Phone:<\/strong> (Lab) +39 0825 299 216\/131<\/pre>\n
Fax:<\/strong> +39 0825 299 641<\/pre>\n
e-mail: antonio.varriale<\/strong>@isa.cnr.it<\/h5>\n
 <\/h5>\n
C<\/em><\/strong>NR People<\/em> WEB Site: <\/strong>http:\/\/www.cnr.it\/people\/antonio.varriale<\/a><\/h5>\n
Keywords: :<\/span><\/b> Proteins, <\/span>Molecular Biology, Biotechnology, Enzymology, Fuorescence, Food Safety and Food Security.<\/span><\/strong><\/h5>\n
Curriculum EN<\/strong>: (click here to view it)<\/h5>\n
Researcher Activities<\/h1>\n
 <\/p>\n
The main interest of the laboratory is on understanding the rules underlying the folding of proteins and how their structure is modified by the interaction with other proteins, nucleic acids and small ligand molecules. To approach these issues we use, and occasionally develop, new, advanced optical methodologies. The acquired knowledge in protein structure is used for the design of innovative diagnostic methods and for other biotechnology applications.<\/p>\n
The focus is to develop and apply advanced luminescence methodologies and optical measurements to solve questions of biochemical and medical interests.\u2028In particular, our interests are focused on the study at a molecular level of the interactions involving proteins, enzymes, nuclei acids as well as small ligand molecules for contributing to shed light to the fields of proteomics, post-proteomics, interatomic and bio\/sensing.\u2028Our lab is equipped with the state-of-art instrumentations for investigating biological interactions by means of FRET, time-resolved FRET, fluorescence polarization, anisotropy decays, fluorescence correlation spectroscopy for single molecule detection, surface plasmon resonance, circular dichroism in the far- and near-UV regions, stopped-flow methodologies, metal enhanced fluorescence.\u2028In addition, the Lab has core collaborations in the fields of bioinformatics, atomic force microscopy, linear spectroscopy, material engineering, and nanotechnology that allow us to handle research projects until they are completely fulfilled.\u2028The Lab is also active in the use of fluorescence to quantify structural features of biological molecules even at nano-scale, and, consequently, to design advanced optical biochips, Lab-on-Chip, or simple disposable biosensors for analyses of high social interest (POCT).\u2028This capability in biophysical methodologies together with expertise in protein biochemistry, molecular genetics and microbiology allows the research team to challenge cutting-edge biochemical questions as well as to rapidly answer to biotechnological requests from SMEs and public institutions.<\/p>\n
Keywords:<\/strong> Protein structure and stability; Biosensors; Diagnostic tools; POCT;<\/p>\n
 <\/p>\n
Key Publications<\/h1>\n
Publications (Last five years)<\/strong><\/p>\n
171. Novel biosensors based on optimized glycine oxidase
\nE. Rosini, L. Piubelli, G. Molla, L. Frattini, M. Valentino, A. Varriale, Sabato D\u2019Auria, L. Pollegioni
\nFEBS Journal (2014)<\/strong> In press<\/p>\n
168. An innovative biophotonic gas sensor for the ultra-sensitive detection of DMMP as a simulant of SARIN
\nK. Bonnot, F. Cuesta-Soto, M. Rodrigo, B. Siegert, A. Varriale, N. Sanchez, Sabato D\u2019Auria, D. Spitzer and F. Lopez-Royo
\nAnalytical Chemistry (ACS) 2014<\/strong> Apr 25. PMID: 2476627<\/p>\n
161. Extending the range of FRET: the Monte Carlo study of the antenna effect.
\nWalczewska-Szewc K, Bojarski P, Sabato D’Auria
\nJ Mol Model. (2013)<\/strong> Oct;19(10):4195-201.<\/p>\n
159. Vesicular and non-\u00advesicular glucosylceramide transport feed distinct glycosylation pathways
\nG. D\u2019Angelo, T.Uemura, CC Chuang, E. Polishchuk, M. Santoro, HO Rekil\u00e4, T. Sato, G. Di Tullio,
\nA. Varriale, SabatoD\u2019Auria, T. Daniele, F. Capuani, L. Johannes, P. Mattjus, F. Platt, A. Harada, MA. De Matteis
\nNature (2013) <\/strong>Aug 4. doi: 10.1038\/nature12423<\/p>\n
158. Fluorescence correlation spectroscopy and molecular dynamics simulations to study the structural futures of the maltotriose-binding protein from Thermus thermophilus
\n<\/em>A. Varriale, A. Marabotti, G. Mei, M. Staiano, and Sabato D\u2019Auria
\nPLOS ONE (2013) <\/strong>Jun 4;8(6):e64840. doi: 10.1371\/journal.pone.0064840.<\/p>\n
155. Amino acid transport in thermophiles: characterization of an arginine-binding protein from Thermotoga maritima.<\/em> 4. A brief thermo-story
\nA. Ausili, M. Staiano, JD. Dattelbaum, A. Varriale, A. Capo, and Sabato D’Auria
\nLife <\/strong>(2013) 3(1), 149-160<\/p>\n
152. An Innovative Plastic Optical Fiber-based Biosensor for new Bio\/applications. The Case of Celiac Disease
\nN. Cennamo, A. Varriale, A. Pennacchio, M. Staiano, D. Massarotti, L. Zeni, and Sabato D\u2019Auria
\nSensors Actuators B Chemical (2013) 176:1008\u20131014.<\/strong><\/p>\n
151. Detection of odorant molecules via surface acoustic wave biosensor array based on odorant-binding proteins
\nF. Di Pietrantonio, D. Cannat\u00e0, M. Benetti, E. Verona, A. Varriale, M. Staiano, and Sabato D\u2019Auria
\nBiosens Bioelectron. 2013 Mar 15;41:328-34<\/strong><\/p>\n
150. Under pressure that splits a family in two. The case of lipocalin family
\nS. Marchal, A. Marabotti, M. Staiano, A. Varriale, T. Domaschke, R. Lange, and Sabato D\u2019Auria
\nPLoS One. 2012;7(11):e50489.<\/strong><\/p>\n
148. A biophotonic sensor for the specific detection of DMMP vapors at the ppb level
\nBonnot, K, Siegert, B, Piazzon, N, Spitzer, D, Sansano, J, Rodrigo, M, Cuesta-Soto, F, Varriale, A, D’Auria, Sabato, Sanchez, N, Lopez-Royo, F, Sanchez, J.J.
\nFuture Security<\/strong> (2012) Volume 318, Pages 428-31.<\/p>\n
147. Determination of benzyl methyl ketone, a commonly used precursor in amphetamine manufacture
\nS. Di Giovanni, A. Varriale, VM. Marzullo, G. Ruggiero, M. Staiano, A. Secchi, L. Pierno, AM. Fiorello and Sabato D\u2019Auria
\nAnalytical Methods (2012) 4, 3558-3564.<\/strong><\/p>\n
143. Porous silicon wafer-based “lab on chip” sensor
\nSabato D’Auria, A. Varriale, G. Ruggiero, M. Staiano
\nEncyclopedia of Metalloproteins  (2012)<\/strong> V. Uversky, RH, Kretsinger, E A. Permyakov (Eds), Springer, New York<\/p>\n
142. A surface plasmon resonance-based biochip to reveal traces of ephedrine
\nA. Varriale, M. Staiano, M. Straianese, M. Marzullo, G, Ruggiero, A. Secchi, M. Dispensa, AM. Fiorello and Sabato D’Auria
\nAnalytical Methods  (2012) 4, 1940-44<\/strong>.<\/p>\n
141. D-Serine-Dehydratase from Saccaromyces cerevisiae<\/em>. A Pyridoxal -5\u2019-phosphate-Dependent Enzyme for Advanced Biotech Applications
\nM. Staiano, M. Strianese, A. Varriale, S. Di Giovanni, D. Scotto di Mase, V. Dell\u2019Angelo, G. Ruggiero,
\nT. Labella, C. Pellecchia and Sabato D\u2019Auria
\nProtein Peptide Letters (2012)<\/strong> Vol. 19, No. 5, 2012.<\/strong><\/p>\n
136. New insight into protein-ligand interactions. The case of the D-galactose\/D-glucose-binding protein from E. coli.
\n<\/em>OV. Stepanenko, OV. Stepanenko, OI. Povarova, AV. Fonin, IM. Kuznetsova, KK. Turoverov, M. Staiano, A. Varriale, and Sabato D’Auria
\nJournal Physical Chem B (2011) 115(12):2765-73<\/strong><\/p>\n
134. Absorption into fluorescence. A method to sense biologically relevant gas molecules
\nM. Strianese, A. Varriale, M. Staiano, C. Pellecchia, and Sabato D\u2019Auria
\nNanoscale (2011) 3:298-302<\/strong><\/p>\n
133. The archeal topoisomerase reverse girase is a helix-destabilizing protein that unwinds four-way DNA functions
\nA. Valenti, G. perugino, A. Varriale, M. Rossi, Sabato D\u2019Auria, M. Ciaramella
\nJ Biol Chem (2010) <\/strong>285: 36532-36541.<\/strong><\/p>\n
128. Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima<\/em>. 2. Molecular organization and structural stability
\nA. Scir\u00e8, A. Marabotti, M. Staiano, L. Iozzino, MS. Luchansky, BS. Der, JD. Dattelbaum, F. Tanfani, and Sabato D\u2019Auria
\nMol Biosyst. (2010) <\/strong>Apr;6(4):687-9<\/p>\n
125. Human galectin-3 interacts with two anticancer drugs: a spectroscopic study
\nV. Bogoeva, A. Varriale, CM. Costance, and Sabato D\u2019Auria
\nProteomics (2010) <\/strong>10,10,1948-53.<\/p>\n
121. Pressure Effects on the structure and stability and of the hyperthermophilic trehalose\/maltose-binding protein from Thermococcus litoralis
\n<\/em>Marchal S., Staiano M, Marabotti A., Vitale A., varriale, A., Lange R., and D\u2019Auria Sabato
\nJ Phys Chem B. (2009) <\/strong>113(38):12804-8.<\/p>\n
120. Tumor specific protein human galectin-1interacts with anticancer agents
\nD`Auria Sabato, Petrova L., John C., Russev G., Varriale, A., Bogoeva V
\nMol Biosyst. (2009) <\/strong>11:1331-6.<\/p>\n
119. FCS-based sensing for the detection of Ocratoxin A and Neomycin in food
\nA. Varriale, M. Staiano,L. Iozzino, L. Severino,  A. Anastasio, ML Cortesi, and Sabato D\u2019Auria
\nProtein Peptide Letters (2009) <\/strong>16,12, 1425-1429.<\/p>\n
117. Structure and stability of a rat odorant-binding protein. Another brick in the wall”
\nScire, A., Marabotti A., Staiano M., Briand L., Varriale A., Bertoli E., Tanfani F., and  Sabato D’Auria
\nJ Proteome Res. (2009) <\/strong>(8):4005-13.<\/p>\n
Research Group<\/h1>\n
Personnel<\/strong><\/p>\n
A strength of the Lab and associated personnel is their many years of experience in biochemistry\/molecular genetics and fluorescence spectroscopy.\u2028This group collectively has 100 man\/years of experience in fluorescence spectroscopy and biochemistry\/ molecular genetics and has authored a large number of manuscripts on this topic. Actually, the Lab plays an important role in excellence networks of European labs for the physical-chemical characterization of biomolecules under severe conditions. The Lab is also member of several European Consortia for the development of frontier methodologies for monitoring food safety and homeland security and Point of Care Tests (PoCT).<\/p>\n
To testify the high standard levels reached from the Lab, we are proud to announce that some of the research projects of the Lab have recently gained the front pages of nine international Journals.<\/p>\n
On July 1st 2007 the American Chemical Society has published a RESEARCH PROFILE on the activity of the Lab (Analytical Chemistry 2007 July 1, page 4746) underlying the cutting-edge results obtained on the detection of traces gluten in food for celiac patients.<\/p>\n
 <\/p>\n
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Name: Antonio Surname: Varriale Skill: Senior Researcher Phone: (Office) +39 0825 299 101 Phone: (Lab) +39 0825 299 216\/131 Fax: +39 0825 299 641 e-mail: antonio.varriale@isa.cnr.it   CNR People WEB Site: http:\/\/www.cnr.it\/people\/antonio.varriale Keywords: : Proteins, Molecular Biology, Biotechnology, Enzymology, Fuorescence, Food Safety and Food Security. Curriculum…
Leggi il seguito<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":23,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"yoast_head":"\nAntonio Varriale - ISTITUTO DI SCIENZE DELL' ALIMENTAZIONE - CNR<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.isa.cnr.it\/web\/?page_id=4038\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antonio Varriale - ISTITUTO DI SCIENZE DELL' ALIMENTAZIONE - CNR\" \/>\n<meta property=\"og:description\" content=\"Name: Antonio Surname: Varriale Skill: Senior Researcher Phone: (Office) +39 0825 299 101 Phone: (Lab) +39 0825 299 216\/131 Fax: +39 0825 299 641 e-mail: antonio.varriale@isa.cnr.it   CNR People WEB Site: http:\/\/www.cnr.it\/people\/antonio.varriale Keywords: : Proteins, Molecular Biology, Biotechnology, Enzymology, Fuorescence, Food Safety and Food Security. 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