{"id":4032,"date":"2015-07-01T12:32:21","date_gmt":"2015-07-01T12:32:21","guid":{"rendered":"http:\/\/lserver.isa.cnr.it\/web\/?page_id=4032"},"modified":"2025-02-05T20:50:40","modified_gmt":"2025-02-05T20:50:40","slug":"sabato-d-auria","status":"publish","type":"page","link":"https:\/\/www.isa.cnr.it\/web\/?page_id=4032","title":{"rendered":"Sabato D’Auria"},"content":{"rendered":"\n\n\n\n\n\n\n
\"dauria\"<\/a><\/td>\n\n

Sabato D’Auria<\/span><\/h1>\n

Research Director<\/h1>\n

Direct: +39 0825 299101
\nFAX: +39 0825 781585<\/h5>\n
Email: sabato.dauria@cnr.it<\/h5>\n

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\n

Research Interests<\/h1>\n

The Laboratory for Molecular Sensing<\/strong><\/span><\/p>\n

\"Molecular<\/p>\n

The main interest of the laboratory is on understanding the rules underlying the folding of proteins and how their structure is modified by the interaction with other proteins, nucleic acids and small ligand molecules. To approach these issues we use, and occasionally develop, new, advanced optical methodologies. The acquired knowledge in protein structure is used for the design of innovative diagnostic methods and for other biotechnology applications.<\/p>\n

The focus is to develop and apply advanced luminescence methodologies and optical measurements to solve questions of biochemical and medical interests.\u2028In particular, our interests are focused on the study at a molecular level of the interactions involving proteins, enzymes, nuclei acids as well as small ligand molecules for contributing to shed light to the fields of proteomics, post-proteomics, interatomic and bio\/sensing.\u2028Our lab is equipped with the state-of-art instrumentations for investigating biological interactions by means of FRET, time-resolved FRET, fluorescence polarization, anisotropy decays, fluorescence correlation spectroscopy for single molecule detection, surface plasmon resonance, circular dichroism in the far- and near-UV regions, stopped-flow methodologies, metal enhanced fluorescence.\u2028In addition, the Lab has core collaborations in the fields of bioinformatics, atomic force microscopy, linear spectroscopy, material engineering, and nanotechnology that allow us to handle research projects until they are completely fulfilled.\u2028The Lab is also active in the use of fluorescence to quantify structural features of biological molecules even at nano-scale, and, consequently, to design advanced optical biochips, Lab-on-Chip, or simple disposable biosensors for analyses of high social interest (POCT).\u2028This capability in biophysical methodologies together with expertise in protein biochemistry, molecular genetics and microbiology allows the research team to challenge cutting-edge biochemical questions as well as to rapidly answer to biotechnological requests from SMEs and public institutions.<\/p>\n

Keywords:<\/strong> Protein structure and stability; Biosensors; Diagnostic tools; POCT;<\/p>\n

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\n

Key Publications<\/h1>\n

Publications (Last five years)<\/strong><\/p>\n

171. Novel biosensors based on optimized glycine oxidase
\nE. Rosini, L. Piubelli, G. Molla, L. Frattini, M. Valentino, A. Varriale, Sabato D\u2019Auria, L. Pollegioni
\nFEBS Journal (2014)<\/strong> In press<\/p>\n

170. A loose domain swapping organization confers a remarkable stability to the dimeric structure of the Arginine Binding Protein from Thermotoga maritima
\nA. Ruggiero, JD Dattelbaum, M. Staiano, R. Berisio, Sabato D\u2019Auria, L. Vitagliano
\nPLOS ONE (2014)<\/strong> In Press.<\/p>\n

169. Characterization of bacterial NMN deamidase as a Ser\/Lys hydrolase expands diversity of serine amidohydrolases.
\nSorci, L., Brunetti, L., Cialabrini, L., Mazzola, F., Kazanov, M.D., D\u2019Auria Sabato, Ruggieri, S., Raffaelli, N.,
\nFEBS Letters (2014),<\/strong> doi: http:\/\/dx.doi.org\/10.1016\/j.febslet.2014.01.063<\/p>\n

168. An innovative biophotonic gas sensor for the ultra-sensitive detection of DMMP as a simulant of SARIN
\nK. Bonnot, F. Cuesta-Soto, M. Rodrigo, B. Siegert, A. Varriale, N. Sanchez, Sabato D\u2019Auria, D. Spitzer and F. Lopez-Royo
\nAnalytical Chemistry (ACS) 2014<\/strong> Apr 25. PMID: 2476627<\/p>\n

167. The mKO: An orange-emitting fluorescence protein. Structure and stability
\nA. Ausili, M. Staiano, A. Marabotti, G. D\u2019Auria, JC. G\u00f3mez-Fern\u00e1ndez, A. Torrecillas, A. Ortiz, Sabato D\u2019Auria
\nJournal Photochem Photobiol B: Biology (2014);<\/strong> 10.1016\/j.jphotobiol.2014.04.028<\/p>\n

166 A Surface Plasmon Resonance based biochip for the detection of Patulin Toxin
\nA. Pennacchio, G. Ruggiero, M. Staiano, G. Piccialli, G,  Oliviero, A. Lewkowicz, A. Synak, Sabato D’Auria
\nOptical Materials (2014)<\/strong> In Press<\/p>\n

165. The trehalose\/maltose-binding protein as a sensitive element of a glucose biosensor
\nA.V. Fonin, O.I. Povarova, M. Staiano, Sabato D\u2019Auria, K. K. Turoverov I.M. Kuznetsova
\nOptical Materials (2014)<\/strong> In Press<\/p>\n

164. Preparation of surface acoustic wave odor sensors by laser-induced forward transfer
\nA. Palla-Papavlu, A. Patrascioiu, F. Di Pietrantonio, J-M. Fern\u00e1ndez-Pradas, D, Cannat\u00e0, M. Benetti, Sabato D\u2019Auria, E. Verona, P. Serra
\nSensors and Actuators B: Chemical<\/strong> (2014) Volume 192, Pages 369\u2013377<\/p>\n

163. Tryptophan-scanning mutagenesis of the ligand binding pocket in Thermotoga maritima<\/em> arginine-binding protein
\nLJ. Deacon, H. Billones, AA. Galyean, T. Donaldson, A. Pennachio, L. Iozzino, Sabato D\u2019Auria, JD. Dattelbaum
\nBiochemie (2014)<\/strong> In Press  doi: 10.1016\/j.biochi.2013.12.011.<\/p>\n

162. The Quaternary Structure of the Recombinant Bovine Odorant-Binding Protein is Modulated by Chemical Denaturants
\nOV. Stepanenko, OV. Stepanenko,  M. Staiano,  IM. Kuznetsova, KK. Turoverov, Sabato D’Auria
\nPLOS ONE (<\/strong>2014) Jan 7;9(1):e85169.<\/p>\n

161. Extending the range of FRET: the Monte Carlo study of the antenna effect.
\nWalczewska-Szewc K, Bojarski P, Sabato D’Auria
\nJ Mol Model. (2013)<\/strong> Oct;19(10):4195-201.<\/p>\n

160. Tailoring Odorant-Binding protein coatings characteristics for Surface Acoustic Wave biosensor development
\nF. Di Pietrantonio, M. Benetti, V. Dinca, D. Cannat\u00e0, E. Verona, Sabato D\u2019Auria, M. Dinescu
\nApplied Surface Science (2013)<\/strong> http:\/\/dx.doi.org\/10.1016\/j.apsusc.2013.10.112<\/p>\n

159. Vesicular and non-\u00advesicular glucosylceramide transport feed distinct glycosylation pathways
\nG. D\u2019Angelo, T.Uemura, CC Chuang, E. Polishchuk, M. Santoro, HO Rekil\u00e4, T. Sato, G. Di Tullio,
\nA. Varriale, SabatoD\u2019Auria, T. Daniele, F. Capuani, L. Johannes, P. Mattjus, F. Platt, A. Harada, MA. De Matteis
\nNature (2013) <\/strong>Aug 4. doi: 10.1038\/nature12423<\/p>\n

158. Fluorescence correlation spectroscopy and molecular dynamics simulations to study the structural futures of the maltotriose-binding protein from Thermus thermophilus
\n<\/em>A. Varriale, A. Marabotti, G. Mei, M. Staiano, and Sabato D\u2019Auria
\nPLOS ONE (2013) <\/strong>Jun 4;8(6):e64840. doi: 10.1371\/journal.pone.0064840.<\/p>\n

157. Physicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum
\n<\/em>A. Vitale, N. Thorne, S. Lovellc, KP. Battailed, X. Hu, M. Shen, Sabato D\u2019Auria,<\/em> DS. Auld
\nPLOS ONE (2013)<\/strong> Jun 5;8(6):e63828.<\/p>\n

156. Interview with Sabato D\u2019Auria, section editor for Chemical Biology
\nSabato D\u2019Auria
\nBMC Biochem. (2013)<\/strong> Jun 14;14(1):14. doi: 10.1186\/1471-2091-14-14.<\/p>\n

155. Amino acid transport in thermophiles: characterization of an arginine-binding protein from Thermotoga maritima.<\/em> 4. A brief thermo-story
\nA. Ausili, M. Staiano, JD. Dattelbaum, A. Varriale, A. Capo, and Sabato D’Auria
\nLife <\/strong>(2013) 3(1), 149-160<\/p>\n

154. Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31-55.
\nIacomino G, Fierro O, Sabato D’Auria, Picariello G, Ferranti P, Liguori C, Addeo F, Mamone G.
\nJ Agric Food Chem.<\/strong> (2013) <\/strong>Vol. 61, Issue 5, 1088-1096.<\/p>\n

153. Amino acid transport in thermophiles: characterization of an arginine-binding protein from Thermotoga maritima<\/em>. 3. Conformational dynamics and stability
\nA. Ausili, A. Pennacchio, M. Staiano, J. D. Dattelbaum, D. Fessas, A. Schiraldi, and Sabato D\u2019Auria
\nJ Photochem Photobiol B. (2013) 118:66-73<\/strong><\/p>\n

152. An Innovative Plastic Optical Fiber-based Biosensor for new Bio\/applications. The Case of Celiac Disease
\nN. Cennamo, A. Varriale, A. Pennacchio, M. Staiano, D. Massarotti, L. Zeni, and Sabato D\u2019Auria
\nSensors Actuators B Chemical (2013) 176:1008\u20131014.<\/strong><\/p>\n

151. Detection of odorant molecules via surface acoustic wave biosensor array based on odorant-binding proteins
\nF. Di Pietrantonio, D. Cannat\u00e0, M. Benetti, E. Verona, A. Varriale, M. Staiano, and Sabato D\u2019Auria
\nBiosens Bioelectron. 2013 Mar 15;41:328-34<\/strong><\/p>\n

150. Under pressure that splits a family in two. The case of lipocalin family
\nS. Marchal, A. Marabotti, M. Staiano, A. Varriale, T. Domaschke, R. Lange, and Sabato D\u2019Auria
\nPLoS One. 2012;7(11):e50489.<\/strong><\/p>\n

149. A new competitive fluorescence immune-assay for detection of Listeria Monocytogenes
\nS Beauchamp, Sabato D\u2019Auria, A. Pennacchio, M. Lacroix
\nAnalytical Methods (2012) DOI: 10.1039\/C2AY25997D<\/strong><\/p>\n

148. A biophotonic sensor for the specific detection of DMMP vapors at the ppb level
\nBonnot, K, Siegert, B, Piazzon, N, Spitzer, D, Sansano, J, Rodrigo, M, Cuesta-Soto, F, Varriale, A, D’Auria, Sabato, Sanchez, N, Lopez-Royo, F, Sanchez, J.J.
\nFuture Security<\/strong> (2012) Volume 318, Pages 428-31.<\/p>\n

147. Determination of benzyl methyl ketone, a commonly used precursor in amphetamine manufacture
\nS. Di Giovanni, A. Varriale, VM. Marzullo, G. Ruggiero, M. Staiano, A. Secchi, L. Pierno, AM. Fiorello and Sabato D\u2019Auria
\nAnalytical Methods (2012) 4, 3558-3564.<\/strong><\/p>\n

146. Alcohol dehydrogenase from the hyperthermophilic archaeon Pyrobaculum aerophilum<\/em>: Stability at high temperature
\nA. Ausili, A. Vitale, F. Rosso, T. Labella, A. Barbarisi, and Sabato D\u2019Auria
\nArchivies Biochem. Biophys. (2012) 525(1):40-6.<\/strong><\/p>\n

145. Engineering resonance energy transfer for advanced immunoassays: The case of celiac disease
\nSabato D’Auria, Apicella E, Staiano M, Di Giovanni S, Ruggiero G, Rossi M, Sarkar P, Luchowski R, Gryczynski I, Gryczynsk Z
\nAnal Biochem (2012) 1;425(1):13-7.<\/strong><\/p>\n

144. Fluorescence-Baserd Biosensors
\nM. Strianese, M. Staiano, G. Ruggiero, T. Labella, C. Pellecchia, and Sabato D’Auria
\nMethod Mol Biol. (2012) 875:193-216<\/strong><\/p>\n

143. Porous silicon wafer-based “lab on chip” sensor
\nSabato D’Auria, A. Varriale, G. Ruggiero, M. Staiano
\nEncyclopedia of Metalloproteins  (2012)<\/strong> V. Uversky, RH, Kretsinger, E A. Permyakov (Eds), Springer, New York<\/p>\n

142. A surface plasmon resonance-based biochip to reveal traces of ephedrine
\nA. Varriale, M. Staiano, M. Straianese, M. Marzullo, G, Ruggiero, A. Secchi, M. Dispensa, AM. Fiorello and Sabato D’Auria
\nAnalytical Methods  (2012) 4, 1940-44<\/strong>.<\/p>\n

141. D-Serine-Dehydratase from Saccaromyces cerevisiae<\/em>. A Pyridoxal -5\u2019-phosphate-Dependent Enzyme for Advanced Biotech Applications
\nM. Staiano, M. Strianese, A. Varriale, S. Di Giovanni, D. Scotto di Mase, V. Dell\u2019Angelo, G. Ruggiero,
\nT. Labella, C. Pellecchia and Sabato D\u2019Auria
\nProtein Peptide Letters (2012)<\/strong> Vol. 19, No. 5, 2012.<\/strong><\/p>\n

140. Extending F\u00f6rster resonance energy transfer measurements beyond 100 \u00c5 using common organic fluorophores: enhanced transfer in the presence of multiple acceptors.
\nMaliwal BP, Raut S, Fudala R, D’Auria Sabato, Marzullo VM, Luini A, Gryczynski I, Gryczynski Z.
\nJ Biomed Opt. (2012) Jan;17(1):011006.<\/strong><\/p>\n

139. New insight in protein-ligand interactions. 2. Stability and properties of two mutant forms of the D-galactose\/D-glucose-binding protein from E. coli.
\n<\/em>Stepanenko OV, Fonin AV, Stepanenko OV, Morozova KS, Verkhusha VV, Kuznetsova IM, Turoverov KK, Staiano M, and D’Auria Sabato
\nJ Phys Chem B.  (2011) Jul 28;115(29):9022-32<\/strong><\/p>\n

138. Long-distance FRET analysis: a Monte Carlo simulation study.
\nBojarski P, Kulak L, Walczewska-Szewc K, Synak A, Marzullo VM, Luini A, and D’Auria Sabato.
\nJ Phys Chem B. (2011) Aug 25;115(33):10120-5.<\/strong><\/p>\n

137. Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein.
\nRuggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D’Auria Sabato, Vitagliano L.
\nActa Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1462-5<\/strong><\/p>\n

136. New insight into protein-ligand interactions. The case of the D-galactose\/D-glucose-binding protein from E. coli.
\n<\/em>OV. Stepanenko, OV. Stepanenko, OI. Povarova, AV. Fonin, IM. Kuznetsova, KK. Turoverov, M. Staiano, A. Varriale, and Sabato D’Auria
\nJournal Physical Chem B (2011) 115(12):2765-73<\/strong><\/p>\n

135. Myoglobobin as a fluorescence probe to sense H2<\/sub>S
\nM. Strianese, F. De Martino, C. Pellecchia, G. Ruggiero, and Sabato D\u2019Auria
\nProtein Peptide Letters (2011) 18(3):282-6<\/strong><\/p>\n

134. Absorption into fluorescence. A method to sense biologically relevant gas molecules
\nM. Strianese, A. Varriale, M. Staiano, C. Pellecchia, and Sabato D\u2019Auria
\nNanoscale (2011) 3:298-302<\/strong><\/p>\n

133. The archeal topoisomerase reverse girase is a helix-destabilizing protein that unwinds four-way DNA functions
\nA. Valenti, G. perugino, A. Varriale, M. Rossi, Sabato D\u2019Auria, M. Ciaramella
\nJ Biol Chem (2010) <\/strong>285: 36532-36541.<\/strong><\/p>\n

132. Denaturation of Proteins with beta-barrel topology induced by guanidinium hydrochloride.
\nOV. Stepanenko, IM. Kuznetsova, VV. Verkusha, M. Staiano, Sabato  D\u2019Auria, KK. Turoverov
\nSpectroscopy (2010)<\/strong> 24, 367-373.<\/p>\n

131.High stability of trehalose\/maltose binding protein from Thermococcus litoralis<\/em> makes it a good candidate as a sensitive element in biosensor systems for sugar control.
\nOI. Povarova, OV. Stepanenko, AI. Sulatskaya, IM. Kuznetsova, KK. Turoverov, M. Staiano, A. Vitale, and Sabato D\u2019Auria
\nSpectroscopy (2010) <\/strong>24: 349-353.<\/strong><\/p>\n

130. Structure and stability of D-galactose\/D-glucose-binding protein. The role of D-glucose binding and Ca ion depletion
\nOV. Stepanenko OI. Povarovaa, OV. Stepanenko, AV. Fonin, IM. Kuznetsova, KK. Turoverov, M. Staiano, and Sabato D\u2019Auria
\nSpectroscopy (2010) <\/strong>24: 355-359<\/strong>.<\/strong><\/p>\n

129. Properties and evolution of an alcohol dehydrogenase from the Crenarchaeota Pyrobaculum aerophilum.
\n<\/em>Vitale A, Rosso F, Barbarisi A, Labella T, and Sabato  D’Auria
\nGene (2010)<\/strong> 1,1-2, 26-31.<\/p>\n

128. Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima<\/em>. 2. Molecular organization and structural stability
\nA. Scir\u00e8, A. Marabotti, M. Staiano, L. Iozzino, MS. Luchansky, BS. Der, JD. Dattelbaum, F. Tanfani, and Sabato D\u2019Auria
\nMol Biosyst. (2010) <\/strong>Apr;6(4):687-9<\/p>\n

127. New trends in bio\/nanotechnology. Stable proteins as advanced molecular tools for health and environment
\nM. Staiano, M. Baldassarre, M. Esposito, R. Vitale, V. Aurilia and Sabato D\u2019Auria
\nEnvironmental Technology (2010) <\/strong>(8-9), 935-42.<\/p>\n

126. Crystal structure of an S-formylglutathione hydrolase from Pseudoalteronomas haloplanktis<\/em> TAC 125
\nV. Alterio, V. Aurilia, A. Romanelli, A. Parracino, M. Saviano, Sabato D\u2019Auria, G.  De Simone
\nBiopolymers (2010) <\/strong>8,669-677.<\/p>\n

125. Human galectin-3 interacts with two anticancer drugs: a spectroscopic study
\nV. Bogoeva, A. Varriale, CM. Costance, and Sabato D\u2019Auria
\nProteomics (2010) <\/strong>10,10,1948-53.<\/p>\n

124. Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritime
\n<\/em>MS Luchansky, BS. Der, D\u2019Auria Sabato, G. Pocsfalvi , L. Iozzino,  JD Dattelbaum
\nMol Biosyst. (2010) <\/strong>1:132-41<\/p>\n

123 Surface acoustic wave biosensor based on a recombinant bovine odorant-binding protein
\nDi Pietrantonio, F, Zaccari, I, Benetti, M, Cannat\u00e0, D, Verona, E, Crescenzo, R, Scognamiglio, V, and Sabato D’Auria
\nLecture Notes in Electrical Engineering<\/strong> (2010),<\/strong> 201-205<\/p>\n

122. Nanostructured silver-based surfaces: new emergent methodologies for an easy detection of analytes
\nStaiano M., Matveva E. Rossi, M, Crescenzo r., Iozzino, L., Gryczniski, I., Gryczniski, Z, and Sabato  D\u2019Auria
\nACS Appl. Mater. Interfaces<\/em><\/strong>, (<\/strong>2009)<\/strong> 1 (12), 2909\u2013291.<\/p>\n

121. Pressure Effects on the structure and stability and of the hyperthermophilic trehalose\/maltose-binding protein from Thermococcus litoralis
\n<\/em>Marchal S., Staiano M, Marabotti A., Vitale A., varriale, A., Lange R., and D\u2019Auria Sabato
\nJ Phys Chem B. (2009) <\/strong>113(38):12804-8.<\/p>\n

120. Tumor specific protein human galectin-1interacts with anticancer agents
\nD`Auria Sabato, Petrova L., John C., Russev G., Varriale, A., Bogoeva V
\nMol Biosyst. (2009) <\/strong>11:1331-6.<\/p>\n

119. FCS-based sensing for the detection of Ocratoxin A and Neomycin in food
\nA. Varriale, M. Staiano,L. Iozzino, L. Severino,  A. Anastasio, ML Cortesi, and Sabato D\u2019Auria
\nProtein Peptide Letters (2009) <\/strong>16,12, 1425-1429.<\/p>\n

118. Structure and dynamics of cold-adapted enzymes as investigated by phosphorescence spectroscopy and molecular dynamics studies. 2. The case of an esterase from Pseudoalteromonas haloplanktis<\/em>”
\nD’Auria, Sabato, Aurilia V., Marabotti A., Gonnelli M., Strambini G.
\nJ Phys Chem B. (2009) <\/strong>113(40):13171-8.<\/p>\n

117. Structure and stability of a rat odorant-binding protein. Another brick in the wall”
\nScire, A., Marabotti A., Staiano M., Briand L., Varriale A., Bertoli E., Tanfani F., and  Sabato D’Auria
\nJ Proteome Res. (2009) <\/strong>(8):4005-13.<\/p>\n

116. Structure and Dynamics of Cold-Adapted Enzymes as Investigated by FT-IR Spectroscopy and MD. The Case of an Esterase from Pseudoalteromonas haloplankti
\nAurilia V, Rioux-Dub\u00e9 JF, Marabotti A, P\u00e9zolet M, and Sabato D’Auria
\nJ Phys Chem B.  (2009) <\/strong>113(22):7753-7761.<\/td>\n<\/tr>\n

\n

Research Group<\/h1>\n

Personnel<\/strong><\/p>\n

A strength of the Lab and associated personnel is their many years of experience in biochemistry\/molecular genetics and fluorescence spectroscopy.\u2028This group collectively has 100 man\/years of experience in fluorescence spectroscopy and biochemistry\/ molecular genetics and has authored a large number of manuscripts on this topic. Actually, the Lab plays an important role in excellence networks of European labs for the physical-chemical characterization of biomolecules under severe conditions. The Lab is also member of several European Consortia for the development of frontier methodologies for monitoring food safety and homeland security and Point of Care Tests (PoCT).<\/p>\n

To testify the high standard levels reached from the Lab, we are proud to announce that some of the research projects of the Lab have recently gained the front pages of nine international Journals.<\/p>\n

On July 1st 2007 the American Chemical Society has published a RESEARCH PROFILE on the activity of the Lab (Analytical Chemistry 2007 July 1, page 4746) underlying the cutting-edge results obtained on the detection of traces gluten in food for celiac patients.<\/p>\n

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Sabato D’Auria Research Director Direct: +39 0825 299101 FAX: +39 0825 781585 Email: sabato.dauria@cnr.it   Research Interests The Laboratory for Molecular Sensing The main interest of the laboratory is on understanding the rules underlying the folding of proteins and how…
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