Paolo Bergamo

Researcher

Direct: +39 0825 299506
Lab: +39 0825 299161
Email: paolo.bergamo@isa.cnr.it

Short CV

Research Interests

The main goal of my research is the understanding of the functional effects of food components. In particular, I am interested in studying the modulation capacity of foods (e.g. milk) or fatty acids on the redox state of the animals, the mitochondrial bioenergetics. Much of my research is aimed at examining the biological activity of conjugated linoleic acid (CLA) and I have a longstanding interest in the evaluation of the mechanisms underlying its pro-oxidant, immune-modulating and anti-cancer activity in vitro and in vivo experimental models. Within the Immunobiology Unit, I deal with the valuation of the consequences produced by the intake of wheat proteins (gliadin) or probiotic bacteria on intestinal antioxidant / detoxifying defences.

 

Key Publications

Bergamo P, Luongo D, Miyamoto J, Cocca E, Kishino S, Ogawa J, Tanabe S, and Rossi M. 2014.

Immunomodulatory activity of a gut microbial metabolite of dietary linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, associated to improved antioxidant/detoxifying defences.    J Funct Foods 11: 192–202.    doi:10.1016/j.jff.2014.10.007

 

Mollica MP, Trinchese G, Cavaliere G, De Filippo C, Cocca E, Gaita M, Della Gatta A, Marano A, Mazzarella G,  and Bergamo P. 2014.

c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway.

J. Lipid Res. 55: 837-49.               http://www.ncbi.nlm.nih.gov/pubmed/24634500

 

Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, and Palmieri G. 2013.

RedOx status, proteasome and APEH: insights into anticancer effects of t10,c12-Conjugated Linoleic Acid isomer on A375 melanoma cells.

PLoS ONE 8(11): e80900.             http://www.ncbi.nlm.nih.gov/pubmed/24260504

 

Lionetti L, Cavaliere G, Bergamo P, Trinchese G, De Filippo C, Gifuni G, Gaita M, Pignalosa A, Donizzetti I, Putti R, Di Palo R, Barletta A, and Mollica MP. 2012.

Diet supplementation with donkey milk up-regulates liver mitochondrial uncoupling, reduces energy efficiency and improves anti-oxidant and anti-inflammatory defences in rats.

Mol. Nutr. Food Res. 56: 1596-1600. http://www.ncbi.nlm.nih.gov/pubmed/22930490

 

Bergamo P, Gogliettino M, Palmieri G, Cocca E, Maurano F, Stefanile R, Balestrieri M, Mazzarella G, David C, and Rossi M. 2011.

Conjugated Linoleic Acid protects against gliadin-induced depletion of intestinal defenses.

Mol. Nutr. Food Res. 55: S248–S256.http://www.ncbi.nlm.nih.gov/pubmed/21954188

 

Bergamo P, Maurano F, D’Arienzo R, David C, and Rossi M. 2008.

Association between activation of phase 2 enzymes and down-regulation of dendritic cell maturation by 9c,11t-Conjugated Linoleic Acid.

Immunol. Lett. 117: 181-190.       http://www.ncbi.nlm.nih.gov/pubmed/18343507

 

Bergamo P, Maurano F, and Rossi M. 2007.

Phase 2 enzymes induction by Conjugated Linoleic Acid improves lupus-associated oxidative stress.

Free Radic. Biol. Med. 43: 71-79.   http://www.ncbi.nlm.nih.gov/pubmed/17561095

 

Bergamo P, Luongo D, Maurano F, Mazzarella G, Stefanile R, and Rossi M. 2006.

Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-FAS lpr mice.

J. Lipid Res. 47:2382-2391.           http://www.ncbi.nlm.nih.gov/pubmed/16877747

 

Research Group

Immunobiology Unit –  FOOD