Angelo Facchiano

Senior Researcher, Dr.,Ph.D.

Direct: +39 0825 299625

Lab +39 0825 299651

Fax: +39 0825 781885

Email: angelo.facchiano@isa.cnr.it

Personal Web Page

Research Interests

Research activity is oriented to investigate structure and function of bio-molecules, from molecular mechanisms of human pathologies to food and plant sciences. Techniques are based on bioinformatics, applied to molecular modelling and simulations, molecular interactions, omics data analysis, development of computational tools and data bases.

Key Publications

Scafuri B, Marabotti A, Carbone V, Minasi P, Dotolo S, Facchiano A. (2016)
A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer.
Sci Rep. 2016 Sep 2;6:32516. doi: 10.1038/srep32516. PMID: 27587238

Dubey A, Facchiano A, Ramteke PW, Marabotti A. (2016)
In silico approach to find chymase inhibitors among biogenic compounds.
Future Med Chem. 2016, 8, 841-851. PMID: 27173139

Dubey A, Marabotti A, Ramteke PW, Facchiano A. (2016)
Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations.
Biochem Biophys Res Commun. 2016, 473, 449-454. doi: 10.1016/j.bbrc.2016.03.028. PMID: 26975469

Romano P, Profumo A, Rocco M, Mangerini R, Ferri F, Facchiano A. (2016)
Geena 2, improved automated analysis of MALDI/TOF mass spectra.
BMC Bioinformatics 2016 Mar 2;17 Suppl 4:61. doi: 10.1186/s12859-016-0911-2. PMID: 26961516

d’Acierno A, Facchiano A, Marabotti A. (2014)
GALT Protein Database: querying structural and functional features of GALT enzyme.
Hum Mutat. 2014 Jul 2. doi: 10.1002/humu.22613. [Epub ahead of print] PMID: 24990533

Salzano M, Marabotti A, Milanesi L, Facchiano A. (2011)
Human aryl-hydrocarbon receptor and its interaction with dioxin and physiological ligands investigated by molecular modelling and docking simulations.
Biochem Biophys Res Commun. 2011, 413, 176-181. PMID: 21871440

Facchiano A, Marabotti A. (2010)
Analysis of galactosemia-linked mutations of GALT enzyme using a computational biology approach.
Proteins Eng Des Sel. 2010, 23, 103-113. Epub 2009 Dec 11. PMID: 20008339

Facchiano A, Facchiano F. (2009)
Transglutaminases and their substrates in biology and human diseases: 50 years of growing.
Amino Acids 2009, 36, 599-614. Epub 2008 Apr 7. PMID: 18597041

Paladino A, Costantini S, Colonna G, Facchiano AM.(2008)
Molecular modelling of miraculin: Structural analyses and functional hypotheses.
Biochem Biophys Res Commun. 2008, 367, 26-32. PMID: 18158914.

Facchiano AM, Costantini S, Di Maro A, Panichi D, Chambery A, Parente A, Di Gennaro S, Poerio E. (2006)
Modelling the 3D structure of WSCI. Probing the reactive site of the inhibitor with two susceptible proteinases, by time-course analysis and molecular dynamics simulations.
Biological Chemistry, 387, 931-940. PMID: 16913843

Marabotti A. and Facchiano A.M. (2005)
Homology modelling studies on human galactose-1-phosphate uridylyltransferase and on its galactosemia-related mutant Q188R provide an explanation of molecular effects of the mutation on homo- and heterodimers.
J. Med. Chem., 48, 773-779. PMID: 15689161

Costantini S., Colonna G., Rossi M., and Facchiano A.M. (2005)
Modelling of HLA-DQ2 and simulations of its interaction with gluten peptides to explain molecular recognition in celiac disease.
J. of Molecular Graphics and Modelling, 23, 419-431. PMID: 15781184

Marabotti A, D’Auria S, Rossi M, Facchiano AM (2004)
Theoretical model of the three-dimensional structure of a sugar binding protein from Pyrococcus horikoshii: structural analysis and sugar binding simulations.
Biochem J. 2004, 380, 677-684. PMID: 15015939

Research Group

Bioinformatics and Computational Biology

Research Area: OMICS