Personale di Ruolo


Dr.Giuseppe Mazzarella


Istituto di Scienze dell' Alimentazione - CNR
Via Roma, 52 A/C
83100 Avellino - Italy

Piano 3 - Stanza n. 9

Tel. +39 0825 299 391 * Tel. +39 0825 121
Fax +39 0825 299 104


Dr. Giuseppe Mazzarella is researcher at the Institute of Food Science and Technology, National Council Research, Avellino.
Born in 1964, he graduated with a first-class honours in Biology in 1990 at the University Federico II, Naples, and obtained the Diploma in Biochemistry and Clinical Chemistry in 1996.
He worked as Research Fellow at the Department of Pediatrics, University Federico II, Naples (Prof. S. Auricchio).
His research interests is on mucosal immunology particularly focussed on the study of the immunopathologicals mechanisms responsible for the permanent intolerance to gliadin in coeliac disease.
He is author of 5 reviews/monographies, 15 original papers and 22 contributions international congresses.
He his a membership of the "Society for Mucosal Immunology" and the "Ceppellini School of Immunology".



1. R.Troncone, L.Greco, M.Mayer, et al: In Siblings of Celiac Children, Rectal Gluten Challenge Reveals Gluten Sensitization Not Restricted To Coeliac HLA" Gastroenterology 1996;111:318-324

2. A.Prisco, R.Troncone, G.Mazzarella , et al: Identical T Cell Recepto _ Chain Rearrangements Are Present In T Cells Infiltrating the Jejunal Mucosa of Untreated Coeliac Patients" Human Immunology 1997;55:22-33

3. R.Troncone, C.Gianfrani, G.Mazzarella, et al: "Majority of Gliadin-Specific T-Cell Clones from Coeliac Small Intestinal Mucosa Produce _Interferon-g and Interleukin-4" Dig Dis Sci. 1998; 43: 156-161

4. R.Troncone, G.Mazzarella, A.Leone, et al: "Gliadin Activates Mucosal Cell-Mediated Immunity In In Vitro Cultured Rectal Mucosa from Coeliac Patients and a Subset of Their Siblings" Gut 1998; 43: 484-489

5. Miralto, G.Barone, G.Romano, et al: " The Insidious Effect of Diatoms on Copepod Reproduction" Nature 1999; 402:173-176

6. M.Russo, R.Palumbo, C.Turco, et al " Quercitin And Anti-Cd95(Fas/Apo1) Enhance Apoptosis In Hpb-All Cell Line" Febs Letters 462(1999) 322-328

7. Korponay-Szabo IR, Sulkanen S, Halttunen T, et al: " Tissue transglutaminase is the target in both rodent and primate tissue for celiac disease-specific autoantibodies" J Pediatr Gastroenterol Nutr 2000;31:520-7

8. VM. Salvati, M Bajaj-Elliott, R Poulsom, et al: "Keratinocyte growth factor and coeliac disease". Gut 2001;49 176-181.

9. D. Luongo, G. Mazzarella, F. Della Ragione, et al " Down-regulation of ERK1 and ERK2 activity during differentiation of intestinal cell line HT29" Molecular and Cellular Biochemistry 231: 43-50, 2002.

10. Mazzarella G, Maglio M, Paparo F, et al: An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients. Gut. 2003 Jan;52(1):57-62. Paper + cover illustration

11. Troncone R, Franzese R, Mazzarella G, et al: Gluten sensitivity in a subset of children withinsulin-dependent diabetes mellitus. Am J Gastroenterol 2003; 98(3): 590-5

12. Esposito C, Paparo F, Caputo I, et al: Expression and Enzymatic Activity of Small Intestinal Tissue Transglutaminase in Coeliac Disease Am J Gastroenterol 2003 Aug;98(8):1813-20.

13. G. Mazzarella , T.T. MacDonald, VM Salvati, P. Mulligan, L.Pasquale, R. Stefanile, P.Lionetti, R. Troncone, G. Monteleone. Activation of signal transducer and activator of transcription 1 in celiac disease. Am J Path 2003;162:1845-1855.

14. Salvati VM, MacDonald TT, del Vecchio Blanco G, Mazzarella G, Monteleone I, Vavassori P, Auricchio S, Pallone F, Troncone R, Monteleone G. Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease. Pediatr Res. 2003 Sep;54(3):312-8. Epub 2003 Jun 04.

15. Virginia Michela Salvati, Giuseppe Mazzarella, Carmen Gianfrani, Megan K. Levings, Rosita Stefanile, Beatrice De Giulio, Gaetano Iaquinto, Nicola Giardullo, Salvatore Auricchio, Maria Grazia Roncarolo, and Riccardo Troncone Recombinant human IL-10 suppresses gliadin-dependent T-cell activation in ex vivo cultured celiac intestinal mucosa. GUT 2005 54: 46-53

16. Maurano, G. Mazzarella, D. Luongo, R. Stefanile, R. D'Arienzo, M. Rossi, S. Auricchio, R. Troncone. Small intestinal enteropathy in NOD mice fed a wheat-containing diet. Diabetologia 2005 Apr 14

17. Sblattero D, Maurano F, Mazzarella G, Rossi M, Auricchio S, Florian F, Ziberna F, Tommasini A, Not T, Ventura A, Bradbury A, Marzari R, Troncone R.  Characterization of the anti-tissue transglutaminase antibody response in nonobese diabetic  mice. J Immunol. 2005 May 1;174(9):5830-6



1. R.Troncone, L.Maiuri, L.Greco, et al (1995): "Mucosal Cell-Mediated Immunity In Coeliac Disease", Dyn Nutr.Res. Basel, Karger, 1995, Vol 4, 107-114.

2. R.Troncone,,L.Greco,M.Mayer,et al :"The Rectal Mucosa In Coeliac Disease". In:"Coeliac Disease". Editors:M.Maki, P.Collin,J.Visakorpi. Coeliac Disease Study Group Tampere 1997 Page 117-124.

3. G.Mazzarella, V.M.Salvati, M.Borrelli, et al: "Cytokine in coeliac disease" J Digest Protec 2000;1 (2):49-56.

4. G.Mazzarella, F.Paparo, M.Maglio, et al: "Organ Culture Of Rectal Mucosa" Methods In Molecular Medicine Vol 41 ( Eds By Dr. Marsh M.) 2000;Cap.12:163-173.

5. Gianfrani C., Rossi M., Mazzarella G., et al: Immunotherapy of coeliac disease: where do we stand? Catassi C., et al (eds) vol. 1, AIC Press, pp 83-88, 2002.