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Dr. Russo
generalist expertise is in the field of basic
biochemistry, cellular and molecular biology. His
specialistic expertise is on cell division cycle
control and apoptosis in human cancer, with
specific emphasis on the regulative role of protein
phosphorylation. Cell division represents a
fundamental biological process whose deregulation
is associated to human degenerative diseases, such
as cancer. As a postdoctoral fellow at Cold Spring
Harbor Laboratory (NY, USA), he carried out work on
cell cycle regulation by protein kinases in
malignant cell lines. At Biological Station Anton
Dohrn of Naples, he expanded his research to
include regulation of cell division cycle during
meiosis. As Senior Scientist at National Research
Council in Italy (Institute of Food Sciences), he
laid the groundwork on how several non-nutritional
components present in the regular diet, or
molecules derived from food transformation, exert,
at molecular level, a protective effect towards
degenerative pathologies. These studies fall in the
field of dietary chemoprevention which refers to
the use of naturally occurring molecules to
prevent, block or retard tumour formation. The goal
is to discriminate between a general antioxidant
activity associated to phytochemicals and their
ability to specifically trigger cell arrest or cell
death in cancer cells. In terms of Public Health,
the result of this research might contribute to
understand the impact of micronutrients on cancer
prevention and other degenerative human
pathologies. As an added value, these studies will
contribute to shed light on the contradictions
governing the field of healthy foods where general
public and patients are often confused by erroneous
messages which magnify the healthy properties of
phytochemicals without specifying if they are used
at pharmacological doses, as dietary supplements or
as simple components of nutraceuticals/functional
food.
The results of
dr. Russo's activity are documented by more than 70
original articles on peer-reviewed journals
(H-index 2012=20 [according to Scopus])
with a total impact factor > 270
(ISI).
Dr. Russo
successfully administered national and European
projects (e.g. staffing, research protections,
budget), collaborated with other researchers, and
produced several peer-reviewed publications from
each project he participated. In summary, dr. Russo
possesses a demonstrated record of accomplished and
productive research projects in areas of high
relevance in the field of Food and
Health.
Short
CV
Nationality:
Italian, born January 13th, 1961; Massa Lubrense,
Napoli, Italy
Current
position
- Senior
Research Scientist (primo ricercatore) at
Institute of Food Sciences (ISA), National
Research Council (CNR), Avellino (Italy) since
2001.
- Head of Diet
& Human Health division at ISA-CNR and
responsible of Food Chemoprevention
unit.
- Associated
Investigator, Stazione Zoologica "Anton Dohrn",
Naples (since 1997).
Education and
training
- Laurea and in
Biological Sciences, Univ. Federico II, Naples,
Italy (1981).
- Research
Doctoral in Biochemical Sciences issued by
associated Universities of Naples and Bari,
Italy (1993).
Professional
Appointments
- 1986-90.
Post-doctoral Fellow, Department of Biochemistry
of Macromolecules, 1st Medical School,
University of Naples.
- 1989.
August-December, Visiting Scientist, Cold Spring
Harbor Laboratory, New York (NY,
USA).
- 1991-93.
Post-doctoral Fellow, Cold Spring Harbor
Laboratory, New York (NY, USA).
- 1994. Staff
Fellow, Department of Biochemistry of
Macromolecules, 1st Medical School, University
of Naples.
- 1995-96.
Research Scientist, Stazione Zoologica "Anton
Dohrn", Naples.
- 1997-Dec 01.
Research Scientist, Institute of Food Sciences,
National Research Council, Avellino,
Italy
- 1995. July.
Visiting Scientist, Station Zoologique
Villefranche-sur-Mer (Nice,
Francia).
- 1995.
November. Visiting Scientist, Osiris
Therapeutics, Inc., Baltimore (MD,
USA).
- 1995.
December. Visiting Scientist, The Institute for
Reproductive Medicine and Science of Saint
Barnabas, West Orange (NJ, USA).
- 1998.
November. Visiting Scientist, Osiris
Therapeutics, Inc., Baltimore (MD,
USA).
- 2000. June.
Visiting Scientist, Van Andel Institute, Grand
Rapids (MI, USA)
- 2010.
November. Visiting Scientist, Department of
Molecular genetics and Microbiology, Stony Brook
University, New York (NY, USA)
- 2011.
June-July. Visiting Scientist, Department of
Molecular genetics and Microbiology, Stony Brook
University, New York (NY, USA)
Grants awarded
(from 2000-present)
- 2000. "Food
flavonoids and their chemopreventive activity
against degenerative diseases". From Istituto
Superiore di Sanita' (Italian governmental
institution).
- 2001.
"Biological activity of vegetable extracts".
From Rimonest Ltd (Nesher, Israel).
- 2002. "Risks
and benefits of dietary antioxidants in the
prevention of chronic and degenerative
pathologies". From Ministero della Salute
(Italian Health Ministry).
- 2004.
"Innovative tests to abolish in vivo methods to
evaluate human toxicological risk caused by
chemical compounds used in several commercial
fields". From Chelab s.r.l. (Italian private
biotechnology firm).
- 2005.
"Protective effect of red wine polyphenols
against chronic and degenerative pathologies".
From Regione Campania (Local County
administration).
- 2007-2009.
"Mapping And Comparing Oils" (MAC-Oils, Contract
no.: 43083). Specific Support Action, Food
Quality and Safety Priority, EU FP6 (scientific
coordinator: Dr. Gian Luigi Russo).
- 2008-2009.
Title: "Biochip to evaluate food toxicity in
humans". Granted by Italian National Research
Council.
- 2009-2010
"Monitoring of environmental contaminants in the
food chain and health effects". Workpackage
within the program "Environment and Health",
granted by Italian National Research
Council.
- 2009-2011:
"Chemoprevention activity of polyphenols
isolated from beers", from an Italian private
biotechnology firm.
- 2011-present.
"Innovative approaches in the evaluation and
prevention of the food exposure to contaminating
toxic persistent and emergent, through the study
of the diet and the debugging of innovative
methods of survey". Istituto Zooprofilattico
Sperimentale (Portici, Italy).
- 2011-present.
"Development of new pharmacological strategies
for the treatment of cognitive dysfunction
associated with aging and psychiatric disorders,
with special reference to psychosis and
neurodegenerative diseases". Granted by Italian
Ministry of University.
- 2011-present.
"The Italian pilot project SANPEI "Healthy as a
Fish": enhancement of Italian native species
from organic aquaculture for school catering.
From The Italian Ministry of
Agriculture.
- 2011-present.
"New functional foods from regional products
possessing healthy properties". C.I.S.I.A.
project. National Research Council.
Editorial/Peer
reviewing activity:
- Editorial
Advisory Board of Biochemical Pharmacology
Journal (Elsevier ISSN 0006-2952).
- Editorial
Advisory Board of Nutrition, Metabolism and
Cardiovascular Diseases (Elsevier ISSN
0939-4753).
- Peer reviewer
for many international journals
- Expert
evaluator in the program Quality of Life and
Management of Living Resources Key Action 6.2.
Expert evaluator for the Mid Term Review in the
program Quality of Life and Management of Living
Resources
Teaching and
educational activity
- 1993-94.
Professor of Genetics, II University of Naples,
Italy.
- 1994-95.
Professor of Biochemistry of Nucleic Acids, II
University of Naples, Italy.
- 1995-96.
Professor of Biochemistry of Nucleic Acids, II
University of Naples, Italy.
- 1999-2000.
Professor of Biochemistry of Marine Organisms,
University of Naples "Federico II",
Italy.
- 2000-2001.
Professor of Biochemistry of Marine Organisms,
University of Naples "Federico II",
Italy.
- 2001-2002.
Professor of Biochemistry of Marine Organisms,
University of Naples "Federico II",
Italy.
- 2003-2004.
Professor of Applied Biotechnology, University
of Naples "Federico II", Italy.
- 2004-2005.
Professor of Applied Biotechnology, University
of Naples "Federico II", Italy.
- 2005-2006.
Professor of Applied Biotechnology, University
of Naples "Federico II", Italy.
- Teaching
activity in CME and master courses in the field
of cancer biology, chemoprevention,
nutrition.
Publications
(2005-2012)
- C. Spagnuolo,
M. Russo, S. Bilotto, I. Tedesco, B. Laratta and
G. L. Russo. Dietary polyphenols in cancer
prevention: the example of the flavonoid
quercetin in leukemia. Ann. NY Acad. Sci.
[accepted for publication]
- Pisapia L,
Del Pozzo G, Barba P, Caputo L, Mita L,
Viaggiano E, Russo GL, Nicolucci C, Rossi S,
Bencivenga U, Mita DG, Diano N. Effects of some
endocrine disruptors on cell cycle progression
and murine dendritic cell differentiation. Gen
Comp Endocrinol [Epub ahead of
print].
- G.L. Russo,
and E. Picano. The effects of radiation exposure
on interventional cardiologists. Eur. Heart J.
33: 423-4 (2012).
- G.L. Russo,
I. Tedesco, M. Russo, A. Cioppa, M.G. Andreasi,
and E. Picano. Cellular Adaptive Response to
Chronic Radiation Exposure in Interventional
Cardiologists. Eur. Heart J. 33: 408-14
(2012).
- M. Russo, C.
Spagnuolo, I. Tedesco, S. Bilotto and and G. L.
Russo. Flavonoid quercetin in disease prevention
and therapy: facts and fancies. Biochem
Pharmacol. 83: 6-15 (2012)
- C. Spagnuolo,
C. Cerella, M. Russo, S. Chateauvieux, M.
Diederich and G. L. Russo. Quercetin
down-regulates Mcl-1 by acting on mRNA stability
and protein degradation. British J Cancer 105:
221-30 (2011).
- I. Tedesco,
M. Russo, and G. L. Russo. Commentary on
"Resveratrol commonly displays hormesis:
Occurrence and biomedical significance". Human
& Experimental Toxicology 29: 1029-31
(2010).
- M. Russo, C.
Spagnuolo, S. Volpe, A. Mupo, I. Tedesco, and
G.L. Russo. Quercetin Induced Apoptosis in
Association with Death Receptors and Fludarabine
in Cells isolated from Chronic Lymphocytic
Leukemia Patients. British J Cancer 103: 642-08
(2010)
- A. Mari, I.
Tedesco, A. Nappo, G. L. Russo, A. Malorni, V.
Carbone. Phenolic compound characterisation and
antiproliferative activity of 'Annurca' apple, a
southern Italian cultivar. Food Chemistry 123:
157-164 (2010)
- M. Russo, C.
Spagnuolo, I. Tedesco and G. L. Russo.
Phytochemicals in Cancer Prevention and Therapy:
Truth or Dare ? Toxins. 2: 517-551.
(2010)
- Russo M, Mupo
A, Spagnuolo C, Russo G. L. Exploring death
receptor pathways as selective targets in cancer
therapy. Biochem Pharmacol. 80: 674-82.
(2010)
- G. L. Russo.
Dietary n-6 and n-3 Polyunsaturated Fatty Acids:
from Biochemistry to Clinical Implications in
Cardiovascular Prevention. Biochem Pharmacol.
77: 937-46. (2009)
- G.L. Russo,
S. Bilotto, G. Ciarcia, E. Tosti. Phylogenetic
conservation of Cytostatic Factor related genes
in the Ascidian Ciona intestinalis. Gene 429:
104-11 (2009)
- Iacomino, G,
Medici, M.C., G. L. Russo. Valproic Acid
Sensitizes K562 Erythroleukemia Cells to
TRAIL/Apo2L-induced Apoptosis. Anticancer Res.
28: 855-64. (2008)
- M.F. Mazzeo,
B. De Giulio, G. Guerriero, G. Ciarcia, A.
Malorni, G.L. Russo and R.A. Siciliano. Fish
authentication by MALDI-TOF mass spectrometry.
J. Agric. Food Chem. 56: 11071-6
(2008).
- G.L. Russo,
G. Ciarcia, E. Presidente, R.A. Siciliano and E.
Tosti. Cytotoxic and Apoptogenic Activity of a
Methanolic Extract from the Marine Invertebrate
Ciona intestinalis on Malignant Cell Lines. Med.
Chem. 4: 106-9 (2008)
- G. L. Russo.
Ins and outs of dietary phytochemicals in cancer
chemoprevention. Biochem Pharmacol. 74: 533-44.
(2007)
- Russo, M.,
Nigro, P., Rosiello, R., D'Arienzo, G. L. Russo.
Quercetin enhances CD95 and TRAIL induced
apoptosis in leukemia cell lines. Leukemia 21:
1130-3. (2007)
- Y. Menezo,
G.L. Russo, E. Tosti, S. El-Mouatassim, M.
Benkhalifa. Expression profile of genes coding
for DNA repair in human oocytes using pangenomic
microarrays, with a special focus on ROS linked
decays. J. Assist Reprod. Genet. 24: 513-520
(2007)
- S. Comes, A.
Locascio, F. Silvestre, M. d'Ischia, G. L.
Russo, E. Tosti, M. Branno, A. Palumbo.
Regulatory roles of nitric oxide during larval
development and metamorphosis in Ciona
intestinalis. Dev. Biol. 306: 772-84
(2007)
- S.
El-Mouatassimi, S. Bilotto, G.L. Russo, E. Tosti
and Y. Menezo APEX/Ref-1 (Apurinic/Apyrimidic
Endonuclease DNA-Repair Gene) Expression in
Human and Ascidian (Ciona intestinalis) Gametes
and Embryos. Mol. Human Reprod. 13: 549-56
(2007)
- L. Tega, K.
Raieta, D. Ottaviani, G. L. Russo, G. Bianco and
A. Carraturo. Catheter-related Bacteremia and
Multidrug-resistant Acinetobacter lwoffii.
Emerging Infectious Diseases. 13: 355-356
(2007)
- A. Di
Finizio, G. Guerriero, G. L. Russo, and G.
Ciarcia. Identification of gadoid species
(Pisces, Gadidae) by sequencing and PCRÐRFLP
analysis of mitochondrial 12S and 16S rRNA gene
fragments. European Food Research &
Technology. 225: 337-344 (2007)
- G. Iacomino,
M.C. Medici, D. Napoli, and G. L. Russo. Effects
of histone deacetylase inhibitors on
p55CDC/Cdc20 expression in HT29 cell line. J.
Cell. Biochem. 99: 1122-1131 (2006)
- P. Coccetti,
V. Zinzalla, G. Tedeschi, G.L. Russo, S.
Fantinato, O. Marin, L. A. Pinna, M. Vanoni and
L. Alberghina. Detection by mass spectrometry of
Sic1 phosphorylation on Ser201 in yeast cells.
Biochem. Biophys. Res. Commun. 346: 786-793
(2006)
- A. Carraturo,
K. Raieta, D. Ottaviani, and G. L. Russo.
Inhibition of Vibrio parahaemolyticus by a
Bacteriocin-Like Inhibitory Substance (BLIS)
produced by Vibrio mediterranei 1. J. Applied
Microbiol. 101: 234-241 (2006)
- I. Tedesco,
A. Nappo, F. Petitto, G. Iacomino, F. Nazzaro,
R. Palumbo, and G. L. Russo. Antioxidant and
cytotoxic properties of lyophilized beer
extracts on HL-60 cell line. Nutrition &
Cancer 52: 74-83 (2005)
- M. Russo, I.
Tedesco, G. Iacomino, R. Palumbo, G. Galano and
G. L. Russo. Dietary Phytochemicals in
Chemoprevention of Cancer. Curr. Med. Chem.
Ð Immun., Endoc. & Metab. Agents 5:
61-72 (2005)
- R.
Carotenuto, M. C. Vaccaro, N. De Marco, M.
Wilding, S. Biffo, P.C. Marchisio, T.
Capriglione, G.L. Russo, and C. Campanella. In
Xenopus laevis oogenesis p27BBP/eIF6 is
phosphorylated and associated with the
cytoskeleton following meiosis resumption. Cell.
Mol. Life Sciences 62: 1641-1652
(2005)
People
- Idolo
Tedesco, CNR Technician, B.Sc. in Science
(Collaboratore tecnico; laurea Scienze
Biologiche)
- Maria Russo,
CNR Technician, B.Sc. in Science (Operatore
tecnico; laurea Scienze Biologiche,
Specializzazione in Biotecnologie)
- Stefania
Bilotto, Doctorate in Advanced Biology (dottore
di ricerca in Biologia Avanzata;
Co.co.co.)
- Carmela
Spagnuolo, Doctorate in Medical Oncology,
Surgery and Clinical Immunology (dottore di
ricerca in Oncologia medica e chirurgica ed
immunologia clinica; assegnista di
ricerca)
- Roberta
Iannitti, B.Sc. in Science (tirocinante; laurea
Scienze Biologiche)
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